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NURB 3150 GI Drugs Study Set Exam
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NURB 3150 GI DrugsStudy Set Exam
Antacids- action - Answer neutralize gastric acid
Antacids- indications - Answer hyperacidity r/t PUD, gastritis, GERD, heartburn
Antacids- Contraindications - Answer renal failure, electrolyte imbalances, Gi
obstruction
Antacids- Adverse Effects - Answer Aluminum + calcium: constipation
Magnesium: diarrhea
Calcium: kidney stones, rebound hyperacidity
Aluminum + magnesium: fluid retention, hypophosphatemia and Hypermagnesia
Aluminum +phosphate: Hypercalcemia
Long-term use: Metabolic alkalosis (esp sodium bicarbonate)
Antacids reduce Quinolone absorption by ____, so you must admin __ before or after the
dose of abx. - Answer 50%, 2
Give antacids 1 or 2 hours before admin of any other med because they interact with
_____ - Answer absorption
Antacids - Answer Aluminum hydroxide (Amphojel)
Calcium carbonate (Tums)
Magnesium hydroxide (Milk of Magnesia)
Sodium bicarbonate
Aluminum and magnesium hydroxides (Mylanta, Moalox)
H2 receptor Antagonists- action - Answer inhibition of gastric acid secretion
H2- indications - Answer GERD, PUD, erosive esophagitis, stress ulcer prophylaxis,
pathologic gastric hypersecretory conditions, zollinger Ellison syndrome
H2-contraindications - Answer elderly, renal dysfunction, children <12yr
, H2- Adverse effects of Cimetidine - Answer constipation, confusion, dry mouth.
elderly/renal insufficiency- CNS effects , decreased libido, impotence, gynecomastia
H2 - adverse effects of ranitidine and famotidine - Answer thrombocytopenia
Cimetidine interactions - Answer Increases blood concentrations of certain drugs
Smoking ______ the effects of H2 drugs - Answer decreases
You should avoid _______ foods and _______ temperatures when taking H2 drugs -
Answer spicy, extreme
H2 receptor Antagonists - Answer famotidine (Pepcid)
nizatidine (Axid)
ranitidine (Zantac)
cimetidine (Tagamet)
Proton Pump Inhibitors- action - Answer irreversibly blocks gastric acid secretion
PPI- indications - Answer GERD, PUD, Zollinger- Ellison syndrome, NSAID induced
ulcers, stress ulcer prophylaxis.
PPIs are used in combo with antimicrobials to treat _____________ - Answer H. Pylori
infection
H Pylori Prevpac - Answer lansprazole
amoxicillin
clarithromycin
Prevpac dosage - Answer PO BID for 10-14 days
PPI- Adverse Effects - Answer Low incidence: H/A, Diarrhea, N/V, Blood dyscrasias
Long Term use: Inc risk for C.diff, Mg depletion, osteoporosis. Achlorhydia
PPI- interactions - Answer - Inc levels of warfarin, phenytoin, and diazepam
-Dec levels of atazanavir, ketoconazole, ampicillin, iron salts, digoxin
True or false: You should take PPIs with food - Answer False. Take on empty stomach
True or false: You can chew or crush PPIU tablets - Answer False, swallow tablets whole
PPIs - Answer omeprazole (Prilosec)
esomeprazole (Nexium)
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