Exam (elaborations)
EBME 306 CONCEPTUAL PROBLEMS QUESTIONS AND ANSWERS
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EBME 306 CONCEPTUAL PROBLEMS QUESTIONS AND ANSWERS
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Name: Score:122 Multiple choice questions
Term 1 of 122
What is more preferred low or high grafting density
Low grafting density is more desirable it has hydration barrier defects
High grafting density restricts mobility and entropy loss
dehydration and membrane destabilization
Pe and UHMWPE cross linked
low modulus
corrosion and biodegrdation
PMMA
bone cement
PEEK
high TG
High modulus, strength and wear resistance
Monolithic devices
- drug is dispered in an inert polymer,
can add porosity if needed
Drug is released by fickian diffusion
Reservior (often membrane-controlled) devices
Drug core surrounded by a static inert diffusional barrier (membrance0 drug release is
controlled by membrane properties or membrane core diffusion
Devices with physical or chemical changes
Chemically changing degradable system s
degraded products released within the body can induce toxic or inflammatory reactions
rate can be controlled for controlled of desired biofunction
,Term 2 of 122
What is first pass metabolism?
Rate of water diffusion in polymer.
Rate of bond cleavage by water
Balance of these two rates determine weather surface or bulk eroding
Femoral Component
Co-CR-MO
(load bearing)
Plastic Spacer
(UHMWPE)
for articulation
Tibial component (titanium and aluminum less stress shielding and osseointegration
The concentration of drug is greatly reduced BEFORE reaching systemic circulation. This
mainly involves liver enzymes, but also includes gastric enzymes, gut wall enzymes, and
bacterial enzymes. Bioavaliability is reduced.
They produce mineralized collagen matrix, they deposite a matrix of collagen and
release calcium, magnesium, and phosphate ions
Term 3 of 122
Explain the structure of a micelle
It occurs due to water or naturally occuring microorganisms
a ball and cylinder
These leads to formation of a liposome
Thermosets tends to exhibit most brittle fracture since strain is restricted crosslinking
Strands alligned with hydrophobic core and philic arms
,Term 4 of 122
wut is Osseoconduction:
biological process of initiating/inducing osteogenesis
Chemical building block in the polymer structure
The main reactants in the polymerization
favorable growth of bone tissue on a surface/matrix
Term 5 of 122
How does PLGA degrade? Explain like copolymer ratio and its kinetics
Alginates, cellulose, gelatin, collagen
PLGA, PMMA, PDMS, PolyHMPA
5:50 is fastest degradation, but PLA degrades slower than PGA
Non surgical cast,
and surgical like wires or pins or plates or screws
End-to-end distance (r) and radius of gyration
Term 6 of 122
What is a homopolymers
formation of new bone
Chemical building block in the polymer structure
Typically above 10,000
contains same repeating unit
, Term 7 of 122
How do thermoplastics fracture?
Low modulus, porous, high remodeling
Whyyy
It has woven bone, the collagen fibers are randomly oriented
Thermoplastics can exhibit both kinds of fracture depending on the temperature
brittle and ductile
High modulus, slow turnover osteonal
WHY
It has stress oriented collagen fiber gives it the higher modulus
Swelling, dissolution, stress cracking, fatigue, impact fracture, decrystallization,
crystallization
Term 8 of 122
When a carbonyl group is attached to two NH groups it is called a what
Zero order release kinetics are most ideal since its linear and does not depend on initial
concentration of the drug
Urea
Ester
Thioester
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