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NURS 8024 Pharm Exam 3 (antimicrobial part 2) questions with answers
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NURS 8024 Pharm Exam 3 (antimicrobial part 2) questions with answers
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NURS 8024 Pharm Exam 3 (antimicrobialpart 2) questions with answers
Bacterial protein synthesis inhibitors - ANSWERS✔✔ Clindamycin
Clindamycin - ANSWERS✔✔ Time dependent killing
Inhibits protein synthesis
Bacteriostatic
90% bioavailability
Clindamycin mechanism of resistance - ANSWERS✔✔ Altered target sites
Active efflux (pushes drug out of the cell)
Clindamycin ADE - ANSWERS✔✔ GI upset
Skin rash
Neutropenia
Superinfections such a c diff pseudomembranous
- don't use if patient has history of c diff
Clindamycin indications - ANSWERS✔✔ Gram positive
Prophylaxis of endocarditis in valve patients with PCN allergy
Oxazolidinones - ANSWERS✔✔ New class of bacterial protein synthesis
inhibitors
Time dependent killing
Prevents formation of ribosome complex
, Bacteriostatic & Bactericidal against strep
Linezolid - ANSWERS✔✔ Protein synthesis inhibitor
100% bioavailability orally
30% CSF penetration
Linezolid ADE - ANSWERS✔✔ Hematologic
Increased thrombocytopenia risk
Anemia, neutropenia, neuropathy
Optic & peripheral neuropathy
Serotonin syndrome with SSRIs
Linezolid Indications - ANSWERS✔✔ Gram positive resistant
VRE, HCAP, CAP
Complicated skin & tissue infections
Off label use for TB
No resistance currently
Fluoroquinolones - ANSWERS✔✔ Norfloxacin (1st gen)
Ciprofloxacin & Ofloxacin (2nd gen)
Levofloxacin (3rd gen)
Moxifloxacin & Gemifloxacin (3rd gen respiratory)
Fluoroquinolones are classified by - ANSWERS✔✔ Generations according to
antimicrobial spectra
1st Generation Fluoroquinolone - ANSWERS✔✔ Narrow gram negative
Norfloxacin
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