Early Menopause
FMP before age 45
Late Menopause
FMP after age 54
Bilateral oophorectomy prior to age 45 increases risks for:
- All cause mortality
- Coronary heart disease
- CVD
- Menopause symptoms
- Worsening mood symptoms
- Higher incidence of Parkinson Disease
- Associated w...
Bilateral oophorectomy prior to age 45 increases risks for:
- All cause mortality
K
- Coronary heart disease
- CVD
- Menopause symptoms
C
- Worsening mood symptoms
- Higher incidence of Parkinson Disease
- Associated with cognitive impairment
LO
Early Menopause Transition (-2)
7 or more days persistent difference in cycle length from previous normal cycle
- Results of increased follicular aging and depletion
YC
- Inhibin B decreases
- FSH increases (Variable)
LOOP Cycles
Explains elevation of Estradiol in perimenopause
D
- Rising FSH levels recruit 2nd follicle during luteal phase which leads to overproduction of
Estradiol
- This causes menstrual changes in future cycles
U
Decreased AMH in Early Menopause Transition
ST
More frequent anovulatory cycles
Decreased Inhibin B in Early Menopause Transition
- Skipped menstrual cycles
- Mastalgia
- Migraine
- Menorrhagia (with LOOP cycles)
- Endometrial Hyperplasia
, Late Menopause Transition (-1)
60 or more days of amenorrhea for women aged 45 years or older
- Women 40-44 years with recurrent episodes of amenorrhea of 60 day for longer within a year
improves prediction of entry into late menopause transition
Late Menopause Transition (-1) Duration
1-3 years
K
Late Menopause Transition (-1) Symptoms
VMS likely
C
STRAW Stage where FSH > 25
Late Menopause Transition (-1)
- VMS
LO
Elevated FSH symptoms in Late Menopause Transition
- Sleep disturbance
YC
- Changes in weight distribution
- Increased variability in cycle length
Decreased Inhibin B in Late Menopause Transition
- Mood changes
D
- Cognitive complaints
- Changes in sexual functioning
- Increased prevalence of anovulation
U
Decreased AMH in Late Menopause Transition
ST
- GSM
- Bone loss
- CVD issues
- Interval of amenorrhea > 60 days
POI
Menopause before age 40
POI diagnosis
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