An experiment is performed in which the sequence of bases coding for the signal
peptide is deleted from an mRNA molecule which codes for a lysosomal enzyme.
When this mRNA is expressed in a cell, the resulting protein would be expected to
be found in the:
cytoplasm
Which of the following is a not a typical component of biological membranes in
eukaryotic cells?
triglycerides
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During translation, covalent bonds are formed between adjacent _______________
by ___________________
amino acids, ribosomal RNA
Proteolytic enzymes that function best at low pH are:
- lysosomal proteins
- synthesized on rough endoplasmic reticulum
Which of the following would you expect to find in both prokaryotes and
eukaryotes?
ribosomes
In the _______, portions of the mRNA transcript are cut out and removed. The
remaining regions of the mRNA called __________________ are ligated back
together and translated in the ______
nucleus, exons, cytoplasm
Hydrogen bonding
,2
- binds purines and pyrimidines to one another to hold the two strands of the DNA
together
- determines the secondary structure of proteins
- keeps water liquid at room temperature
- permits bases in RNA to bind to bases in DNA during transcription
The three-dimensional shape (tertiary structure) of a protein results largely from
the interaction of the ______ with one another or with water
r-groups
The Signal Recognition Particle (SRP) plays an important role in the synthesis of
some proteins, and is composed of proteins and a small molecule of RNA. You can
conclude that the nucleic acid component of this protein
was synthesized in the nucleus from a DNA template
In 1483, Richard III, had his two nephews, ages 9 and 12 arrested and confined to
the tower of London. They were never again seen alive outside the Tower, and
were presumed murdered. In 1674, two small skeletons were found in a closet
beneath a stairway and assumed to be the remains of the two boys. Which of the
following would be consistent with the skeletons belonging to the Richard's
nephews?
The growth plates had not closed so that the diaphysis and epiphyses of the long
bones were separate structures
A cell's response to hormone depends most importantly on
The availability of a receptor specific for the hormone
The protein diagramed in the accompanying figure would
be synthesized on free ribosomes
Myosin and kinesin which are cytoplasmic proteins, both:
, 3
- are ATPases
- undergo a structural change after converting ATP to ADP and inorganic
phosphate
A pathologist finds a tumor in cartilage and classifies it as an adenocarcinoma.
You can conclude that the tumor originated
as an epithelial cell in glandular epithelium
For all proteins, the first AUG in the ______ that is encountered by the small
ribosomal subunit is known as the _______ and serves to _______
mRNA, start codon, determine the register or reading frame for protein synthesis
The types of cartilage are differentiated from one another by:
the type and mix of extracellular proteins in the extracellular matrix
Vitamin D is a steroid hormone that plays an important role in calcium
metabolism, especially the uptake of calcium from the intestine. One step in the
production of this hormone is the irradiation of _________ in ___________ by
ultraviolet light.
cholesterol and keratinocytes
Marfan syndrome is an inherited disorder that results in connective tissue
abnormalities. The syndrome is usually caused by a mutation in a gene for fibrillin
that leads to the improper folding of the fibrillin protein. The misfolded protein
appears to interfere with the proper assembly of elastic fibers, which are composed
of elastin and fibrillin. Symptoms of the syndrome are associated with defects in
the skeleton, eyes, and cardiovascular system. Marfan victims tend to be tall, with
disproportionately long arms, fingers, and toes. Typically they have an unusually
long lower half of the body, and unusually flexible joints.
Mary Queen of Scots is thought to have had Marfan syndrome although the
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