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NURS 8024 Pharm Exam 3 (antimicrobial part 2) Qs & As
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NURS 8024 Pharm Exam 3 (antimicrobial part 2) Qs & As
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NURS 8024 Pharm Exam 3 (antimicrobial part 2) Qs & AsLinezolid Indications Correct Ans-Gram positive resistant
VRE, HCAP, CAP
Complicated skin & tissue infections
Off label use for TB
No resistance currently
Fluoroquinolones Correct Ans-Norfloxacin (1st gen)
Ciprofloxacin & Ofloxacin (2nd gen)
Levofloxacin (3rd gen)
Moxifloxacin & Gemifloxacin (3rd gen respiratory)
Fluoroquinolones are classified by Correct Ans-Generations according to antimicrobial
spectra
1st Generation Fluoroquinolone Correct Ans-Narrow gram negative
Norfloxacin
2nd Generation Fluoroquinolone Correct Ans-Broad- gram negative and gram positive
Cipro & ofloxacin
, NURS 8024 Pharm Exam 3 (antimicrobial part 2) Qs & As
3rd generation Fluoroquinolone Correct Ans-More gram positive than gram negative
Levofloxacin
Moxifloxacin
Gemifloxacin
-moxi and gemi are respiratory Fluoroquinolones
Fluoroquinolones MOA Correct Ans-Inhibits DNA synthesis
Bactericidal
Concentration dependent killing
Resistance- target sites altered by mutation & change in sensitivity of target enzymes
Bacterial protein synthesis inhibitors Correct Ans-Clindamycin
Clindamycin Correct Ans-Time dependent killing
Inhibits protein synthesis
Bacteriostatic
90% bioavailability
Clindamycin mechanism of resistance Correct Ans-Altered target sites
Active efflux (pushes drug out of the cell)
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