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Exam (elaborations)

BCPS Exam August 2024 LATEST UPDATE

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  • BCPS
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  • BCPS

Unpaired T-test - ANSWER Continuous data 2 independent samples Paired T-test - ANSWER Continuous data 2 paired samples ANOVA - ANSWER Continuous outcome data Categorical exposure data 3+ independent variables

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  • September 26, 2024
  • 88
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • bcps
  • BCPS
  • BCPS
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shantelleG
BCPS Exam August 2024
LATEST UPDATE
Unpaired T-test - ANSWER Continuous data
2 independent samples


Paired T-test - ANSWER Continuous data
2 paired samples


ANOVA - ANSWER Continuous outcome data
Categorical exposure data
3+ independent variables


ANCOVA - ANSWER Continuous outcome data
Categorical exposure data
3+ independent variables
Controls for covariates


Wilcoxon Rank Sum Test (Mann-Whitney U Test) - ANSWER Ordinal data
2 independent samples


Wilcoxon Signed Rank Test - ANSWER Ordinal data
2 paired samples

, Chi Squared Test - ANSWER Categorical data
2 independent samples
Values >5


Fisher's Exact Test - ANSWER Categorical data
2 independent samples
Values <5




When to cardiovert AF - ANSWER AF >48h, anticoagulate for at least 3 weeks
before cardioversion and at least 4 weeks after cardioversion regardless of
CHADS2VASc score


May utilize a TEE to visualize the atria to skip the anticoagulation prior to
cardioversion


HASBLED - ANSWER HTN (>160)
Abnormal renal (SCr >2.26, dialysis)
Abnormal liver (3x ULN)
Stroke (hx)
Bleed (hx or tendency)
Labile INR
Elder (>65)
Antiplatelets/NSAIDs

, EtOH >8drink/wk


≥3 high risk


Warfarin - ANSWER MOA: Inhibits vitamin K epoxide reductase, preventing
production of clotting factors 2 (72h), 7 (6h), 9 (24h), 10 (36h) and inhibits
activation of protein C and S


S-warfarin is 5x more potent than R-warfarin


Antibiotics reduce vitamin K synthesis by the intestinal flora


Warfarin clearance affected by amiodarone, propafenone, cimetidine


Enzyme inducers - ANSWER phenytoin
phenobarbital
carbamazepine
rifampin
St. John's Wort


Enzyme inhibitors - ANSWER fluconazole
azithromycin
Bactrim
Flagyl
amiodarone

, Dabigatran for AF - ANSWER 150mg twice daily
75mg twice daily for CrCl 15-30 or CrCl 30-50 with ketoconazole or dronedarone


Avoid with CrCl <15, dialysis, rifampin, CrCl 15-30 with amiodarone, verapamil,
ketoconazole, dronedarone, diltiazem, clarithromycin


Bleeding, dyspepsia, cannot use pillbox


To warfarin: Overlap by 3 days (CrCl >50), 2 days (CrCl 31-50), or 1 day (CrCl 15-30)


From warfarin: INR <2


Rivaroxaban for AF - ANSWER 20mg daily with meals
15mg daily with meals for CrCl 15-50 or dialysis


Avoid with rifampin, phenytoin, carbamazepine, St. John's Wort, protease
inhibitors, azoles, conivaptan


To warfarin: Bridge with parenteral anticoagulant


From warfarin: INR <3


Apixaban for AF - ANSWER 5mg twice daily

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