KUBY IMMUNOLOGY 7TH EDITION BY OWEN TEST BANK CONTAINING QUESTIONS WITH CORRECT ANSWERS
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Course KUBY IMMUNOLOGY 7TH EDITION
KUBY IMMUNOLOGY 7TH EDITION BY OWEN TEST BANK CONTAINING QUESTIONS WITH CORRECT ANSWERS
Four Types of Hypersensitivity Reactions - correct answers-Type I, Type II, Type III, & Type IV
Type I Hypersensitivity - correct answers-Allergy & Atopy (IgE)
Type II Hypersensitivity - correct answers-A...
KUBY IMMUNOLOGY 7TH EDITION BY OWEN
TEST BANK CONTAINING QUESTIONS WITH
CORRECT ANSWERS
Four Types of Hypersensitivity Reactions - correct answers-Type I, Type II, Type III, & Type IV
Type I Hypersensitivity - correct answers-Allergy & Atopy (IgE)
Type II Hypersensitivity - correct answers-Ab-mediated hypersensitivity (IgG & IgM)
Type III Hypersensitivity - correct answers-Immune complex-mediated hypersensitivity
(Immune-complexes)
Type IV - correct answers-Delayed Type Hypersensitivity (DTH) (T-Cells)
3 Mechanisms of Type II Hypersensitivity - correct answers-- Ab can activate complement ---
Mac
-Ab can mediate ADCC
- Ab can serve as Opsonin
Transfusion Reactions, Hemolytic diseases of the newborn, & Hemolytic Anemia (drug induced)
is what kind of Hypersensitivity Reaction? - correct answers-Type II Hypersensitivity Reaction
Concerning Hemolytic Disease of the Newborn, why is the first pregnancy not severely
affected? - correct answers-- Primary Response: IgM
- Secondary Response: IgG
What can induce Hemolytic Anemia? - correct answers-Drugs: Pennicillin, Streptomycin,
Ibuprofen, Naproxen.
- Drug gets absorbed into membrane proteins. Act as new Ag.
,What triggers a Type III Hypersensitivity Reaction? - correct answers-- Caused by large amounts
of immune complexes that arn't removed by normal mechanisms.
- Immune complexes = Ag+Ig (soluble)
Where can Type III Hypersensitivity Reactions occur? - correct answers-Depends on where the
Immune Complexes are Deposited.
- Near site of entry (localized)
- If it enters the blood (synovial membrane of joints, glomerular basement membrane, blood
vessel walls)
4 step mechanism of Type III Hypersensitivity Reactions - correct answers-1. Immune complex
activates complement
2. generate anaphylatoxins(C3a, C4a, C5a)
3. Recruits Neutrophils & granule release)
4. Anaphyltoxins cause mast cell degranulation
Arthus Reaction - correct answers-Localized Type III Hypersensitivity Reaction. Occurs when Ag
is applied subcutanously to an individual w/ high corresponding Ab.
Serum Sickness - correct answers-Late 19th Century- bacterial infections were treated by
injecting horse serum from horses immunized to a particular bacterial infection.
Farmers Lungs - correct answers-Type III Hypersensitivity Reaction that occurs when moldy hay
is inhaled.
Diseases resulting from Type III Hypersensitivity Reactions - correct answers-- Autoimmune
diseases
- systemic lupus erythematosus (SLE)
- Rheumatoid Artheritis
, - Multiple Sclerosis
- Hepatitis
4 step mechanism of a Type IV Hypersensitivity Reaction - correct answers-1. Th Cell encounters
Ag
2. Th Cell secrete cytokines that induced localized inflammatory reaction
3. Delayed-Type Hypersensitivity Reaction
4. Cytokines cause large influx of Mac's which cause tissue damage
Hallmarks of Type IV Hypersensitivity Reaction (DTH) - correct answers-- Delayed time for
reaction to develope (1-3 days)
- Purely cell-mediated rather than Ab-mediated
- Recruitment of Mac's (as opposed to neutrophils in type III Hypersensitivity reaction)
Primary & Secondary Ag exposure in DTH - correct answers-Primary- SENSITIZATION PHASE,
APC "sensitizes" the DTH-mediating cells which are typically Th1 cells
Secondary- Induces effector phase of DTH. Sensitized Th1 cells secrete cytokines & chemokines
to activate and recruit Macs.
Granuloma - correct answers-Walls off organism in the infected tissue. Macrophage lytic
enzymes damage the body tissue.
Test used to indicate prior exposure to M. tuberculosis - correct answers-Skin Test - PPD
(bacterial cell wall protein) is injected intradermally. Development of firm, red swollen site of
injection within ~48-72 hrs indicates positive test. (DTH)
Contact Dermatitis - correct answers-A Type IV Hypersensitivity Reaction- Occurs if a reactive
chemical compound binds to skin proteins. Modified proteins are then presented to T-cells.
- can be induced by pharmaceuticals, cosmetics, metal ions.
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