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Coagulation – CSMLS |100+ Questions And Answers With Verified Solutions Latest Updated 2024
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Coagulation – CSMLS |100+ Questions And Answers With Verified Solutions Latest Updated 2024
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Coagulation – CSMLS |100+ QuestionsAnd Answers With Verified Solutions
Latest Updated 2024
What are the requirements of normal blood flow? - ANSWER✔✔ smooth blood
vessels
allowing blood to escape in the surrounding tissues
What is the timeline for vascular injury (after the sub endothelium is exposed) -
ANSWER✔✔ 1-2 seconds: vessel constricts, PLTs adhere
10-20 seconds: PLT aggregate
1-3 minutes: PLT plug formed, reinforced with fibrin
3-5 minutes: PLT/fibrin plug contracts
5-10 minutes: plug is tight and stable
hours: repair starts, plug is lysed to reestablish normal flow
What is involved in primary hemostasis? - ANSWER✔✔ PLTs and vascular
response to vessel injury
What is involved in secondary hemostasis? - ANSWER✔✔ formation of a fibrin
clot
What are the four main components of a hemostatic system? - ANSWER✔✔ blood
vessels and surrounding tissues
platelets
plasma proteins (coag factors)
fibrinolytic proteins
,What are the procoagulant properties of vessels? - ANSWER✔✔ vasoconstriction
by smooth muscles
binding of procoagulant proteins and PLTs to exposed collagen
tissue factor exposed on sub endothelial tissue
What are the anticoagulant properties of vessels? - ANSWER✔✔ smooth, intact
surface
secretion of PLT function inhibitors
secretion of coag factor inhibitors (tissue factor pathway inhibitor)
site of membrane bound regulation of thrombomodulin
support of fibrinolysis by release of tissue plasminogen activator
What is von Willebrands factor? - ANSWER✔✔ glycoprotein that promotes PLT
adhesion
promotes plt:plt interaction
carrier molecule for factor VIII
synthesized by endothelial cells, megakaryocytic and plt
PLT role in hemostasis - ANSWER✔✔ adhesion: plt become spherical and release
contents
aggregation: plt bind to each other and cross link with fibrinogen - requires ATP
and calcium
secretion: release contents promoting further plt activity
Is plt adhesion reversible? - ANSWER✔✔ yes
, is plt aggregation reversible? - ANSWER✔✔ no
in order for plt to function efficiently there must be: - ANSWER✔✔ adequate
numbers
normal function
vWF
fibrinogen
the intrinsic pathway of coagulation is initiated by exposure to? - ANSWER✔✔ a
negatively charged surface
What does the contact of XII, prekallikrein and HMWK with a negatively charged
surface result in? - ANSWER✔✔ formation of XIIa
XIIa activates? - ANSWER✔✔ XI to XIa
XIa activates? - ANSWER✔✔ IX to IXa
IXa forms a complex with VIIIa-Ca-PL (platelet phospholipid) to act on? -
ANSWER✔✔ complex: IXa-VIIIa-Ca-PL
acts on X to form Xa
The extrinsic pathway of coagulation is initiated by exposure to? - ANSWER✔✔
tissue factor 3
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