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BIO 467-Amyotrophic Lateral Sclerosis Exam Questions and Answers
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BIO 467-Amyotrophic Lateral Sclerosis Exam Questions and Answers
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BIO 467-Amyotrophic Lateral SclerosisExam Questions and Answers
amyotrophic iilateral iisclerosis ii- iiCorrect iiAnswers ii-what iidoes iiALS iistand iifor
progressive iineurodegenerative iidisease iithat iiaffects iinerve iicells iiin iithe iibrain iiand
iispinal iicord ii- iiCorrect iiAnswers ii-definition iiof iiALS
amyotrophy ii- iiCorrect iiAnswers ii-atrophy iiof iimuscle iifibers
lateral iisclerosis ii- iiCorrect iiAnswers ii-hardening iiof iithe iianterior iiand iilateral iicolumns
iiof iithe iispinal iicord
muscle iiweakness
atrophy
stiffness
twitching ii(fasciculation) ii
cramping iiof iimuscles ii(especially iiin iihands iiand iifeet)
impairment iiof iithe iiuse iiof iithe iiarms iiand iilegs ii- iiCorrect iiAnswers ii-ALS iisymptoms
dysphagia ii- iiCorrect iiAnswers ii-difficulty iiin iiswallowing
dysarthia ii- iiCorrect iiAnswers ii-difficulty iiin iispeech
dysphonia ii- iiCorrect iiAnswers ii-change iiin iivoice iiquality
als iisymptoms ii- iiCorrect iiAnswers ii-Dysphagia
Dysarthria ii
Dysphonia
Respiratory iiInsufficiency ii
Weight iiloss
Fatigue ii
Pain ii
Emotional iiLability ii(Depression/anxiety)
ALS iiPathology ii- iiCorrect iiAnswers ii-ALS iiis iicharacterized iiby iimotor iineuron
iidegeneration iiand iideath iiwith iigliosis iireplacing iilost iineurons ii
, cortical iimotor iicells ii(pyramidal iiand iiBeta iicells) iidisappear iileading iito iiretrograde
iiaxonal iiloss iiand iigliosis iiin iithe iicorticospinal iitract ii
this iigliosis iiresults iiin iithe iibilateral iiwhite iimatters iichanges iisometimes iiseen iiin iithe
iibrain iiMRI ii
the iispinal iicord iibecomes iiatrophic. iithe iiventral iiroots iibecome iithin, iiand iithere iiis iia
iiloss iiof iilarge iimyelinated iifibers iiin iimotor iinerves ii
the iiaffected iimuscles iishow iidenervation iiatrophy iiwith iievidence iiof iireinnervation iisuch
iias iifiber iitype iigrouping
motor iinerve iicells iiin iithe iianterior iihorns iiof iithe iispinal iicord iiand iiin iithe iimotor iinuclei
iiof iithe iibrain iistem iiare iilost iiaffecting iithe iiinnervation iiof iithe iimuscle ii- iiCorrect
iiAnswers ii-ALS iieffect iion iimuscle
spinal iitap
x-rays ii(MRI)
Myelogram iiof iicervical iispine ii- iiCorrect iiAnswers ii-diagnosis iiof iiALS ii
difficult iito iidiagnose iibecause iiit iihas iisimilar iisymptoms iito iiother iineuromuscular
iidisorders
fALS iicaused iiby iimutant iiSuperoxide iiDismutase ii(SOD) ii- iiCorrect iiAnswers ii-genetics
iiof iiALS
SOD1 iimutations ii- iiCorrect iiAnswers ii-most iiare iiautosomal iidominant, iibut iia iifew
iishow iilower iipenetrance iiand iiare iirecessively iiinherited
a4v ii- iiCorrect iiAnswers ii-most iisevere iiand iiaggressive iiform iiof iiSOD1 iimutation
early iionset, iishort iisurvival ii
limited iiupper iineuron iiinvolvement ii
most iicommon iiin iithe iius
extremely iiunstable
Superoxide iiDismustase ii1 ii(SOD1) ii- iiCorrect iiAnswers ii-ubiquitous iicytosolic iiprotein ii
comprised iiof ii153 iiaa iiwith iian iiapproximate iimolecular iiweight iiof ii16kDA iiand iiis iian
iiactive iihomodimer ii
each iione iiof iitwo iidimers iiof iiSOD1 iibinds iia iiCu++ iiand iia iiZn__ iiion
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