PC 707 Final Safety Exam Questions And
Correct Answers
IgE mediated allergic reaction that occurs after the 2nd exposure to the antigen? -
Anwer Type I Immediate hypersensitivity
Delayed Allergic reaction involving T cell in the skin? - Anwer Type IV Reaction
Primary treatment for a Type 1 Allergic response? - Anwer Epinephrine
Adjunctive treatment for a Type 1 Allergic response - Anwer ‣ H1 Blockers
‣ Corticosteroids help prevent bi phasic reactions
‣ Bronchodilators provide some relief-
One of the most Severe forms of a Type IV allergic reactions. - Answer ‣ Stevens
Johnson Syndrome
‣ Toxic epidermal necrolysis
If considering a drug "re challenge" after reaction what are some key things the APRN
must consider? - Answer ‣ What drug the patient reacted to
‣ The severity of the reaction (never again in Type I or severe type IV) *most important*
What Black Box Warning does Carbamazepine & Lamictal carry? - Answer Potential
life-threatening dermatologic reaction, including Steven's Johnson and Toxic Epidermal
Necrolysis
What Black Box Warning does Promethazine (Phenergan)
, antiemetic carry? - Answer Potential for life threatening respiratory depression in
children.
What Black Box Warning do Fluoroquinolones carry? - Answer Potential for tendon
rupture
What Black Box Warning does SSRIs carry? - Answer Potential increased risk of suicide
in teens.
What Black Box Warning does opioids carry? - Answer Combining opioids &
benzodiazepines can cause extreme sleepiness, slowed breathing & death
Insulin/Sulfonaureas adverse effect - Answer Hypoglycemia!
Tricyclic Antidepressants - Answer Very risky for overdose
Nitrofurantoin (Macrobid) adverse effect - Answer Pulmonary Toxicity (rare )
Proton Pump Inhibitors Increases the risks for - Answer ‣ Upon starting: Community
acquired pneumonia
‣ Over time more likely to get infections like TB
‣ Long-term use may be associated with an increased risk of fractures over time
Bisphosphonates potential risk - Answer osteonecrosis of the jaw
Over a lifetime, kidneys shrink & there is a decline in renal blood flow. Why does this
need to be a prescribing consideration? - Answer Decreased renal clearance of drugs
With age, the liver size decreases, as does blood flow & first-pass metabolism. Why is
this a prescribing consideration? - Answer Because liver size decreases, so does the
Correct Answers
IgE mediated allergic reaction that occurs after the 2nd exposure to the antigen? -
Anwer Type I Immediate hypersensitivity
Delayed Allergic reaction involving T cell in the skin? - Anwer Type IV Reaction
Primary treatment for a Type 1 Allergic response? - Anwer Epinephrine
Adjunctive treatment for a Type 1 Allergic response - Anwer ‣ H1 Blockers
‣ Corticosteroids help prevent bi phasic reactions
‣ Bronchodilators provide some relief-
One of the most Severe forms of a Type IV allergic reactions. - Answer ‣ Stevens
Johnson Syndrome
‣ Toxic epidermal necrolysis
If considering a drug "re challenge" after reaction what are some key things the APRN
must consider? - Answer ‣ What drug the patient reacted to
‣ The severity of the reaction (never again in Type I or severe type IV) *most important*
What Black Box Warning does Carbamazepine & Lamictal carry? - Answer Potential
life-threatening dermatologic reaction, including Steven's Johnson and Toxic Epidermal
Necrolysis
What Black Box Warning does Promethazine (Phenergan)
, antiemetic carry? - Answer Potential for life threatening respiratory depression in
children.
What Black Box Warning do Fluoroquinolones carry? - Answer Potential for tendon
rupture
What Black Box Warning does SSRIs carry? - Answer Potential increased risk of suicide
in teens.
What Black Box Warning does opioids carry? - Answer Combining opioids &
benzodiazepines can cause extreme sleepiness, slowed breathing & death
Insulin/Sulfonaureas adverse effect - Answer Hypoglycemia!
Tricyclic Antidepressants - Answer Very risky for overdose
Nitrofurantoin (Macrobid) adverse effect - Answer Pulmonary Toxicity (rare )
Proton Pump Inhibitors Increases the risks for - Answer ‣ Upon starting: Community
acquired pneumonia
‣ Over time more likely to get infections like TB
‣ Long-term use may be associated with an increased risk of fractures over time
Bisphosphonates potential risk - Answer osteonecrosis of the jaw
Over a lifetime, kidneys shrink & there is a decline in renal blood flow. Why does this
need to be a prescribing consideration? - Answer Decreased renal clearance of drugs
With age, the liver size decreases, as does blood flow & first-pass metabolism. Why is
this a prescribing consideration? - Answer Because liver size decreases, so does the
