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HPRS 2301 Unit 4 Exam Questions With 100% Verified Answers

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HPRS 2301 Unit 4 Exam Questions With 100% Verified Answers What is atherosclerosis? - answerHardening of the arteries caused by the formation of fibro- fatty lesion *plaque* within the vessel wall What are the main causes of atherosclerosis? - answer1. A genetic component 2. Hypercholesterolem...

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  • September 30, 2024
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HPRS 2301 Unit 4 Exam Questions With
100% Verified Answers


What is atherosclerosis? - answer✔Hardening of the arteries caused by the formation of fibro-

fatty lesion *plaque* within the vessel wall


What are the main causes of atherosclerosis? - answer✔1. A genetic component


2. Hypercholesterolemia

3. Cigarette smoking, obesity, hypertension and diabetes

Out of the 3 causes for atherosclerosis, which can be considered a *major risk factor*? -

answer✔Hypercholesterolemia


What is hypercholesterolemia? - answer✔Excess cholesterol in blood; heart disease


What are the four steps in the pathogenesis of atherosclerosis? - answer✔1. Endothelial cell

injury

2. Migration of inflammatory cells

3. Lipid accumulation and smooth muscle cell proliferation

4. Plaque structure

, ©BRAINBARTER 2024/2025


What happens in endothelial cell injury? - answer✔The endothelial cells that line the wall of the

blood vessel are damaged due to cigarette smoking, elevated LDL, immune mechanisms, and

hypertension


What does it mean when an individual has elevated LDL - answer✔The high levels of *low

density proteins* known as *bad cholesterol* result in the buildup of cholesterol in the arteries


What happens in the migration of inflammatory cells? - answer✔1. The endothelial cells release

chemicals that attract and bind the cells of the inflammatory response and monocytes towards the

area

2. The endothelial cells also express adhesion molecules that indicate to the inflammatory cells

and monocytes that this is the site where the endothelial cell is damaged


What happens during lipid accumulation and smooth muscle cell proliferation? - answer✔1.

Monocytes transform into macrophages and release a chemical that is based on O2 species that

oxidize the LDL, once it becomes oxidized they then ingest the LDL and transform into *foam

cells*

2. Macrophages can also release growth factors that cause the migration and proliferation of

smooth muscle cells, lymphocytes, and fibroblasts


foam cells - answer✔The characteristic initial lesion of atherosclerosis, also known as a fatty

streak


When do fatty streaks appear? - answer✔1. May form within the first year of life

, ©BRAINBARTER 2024/2025


2. May increase in numbers by the second decade of life, and remain static or regress


What happens during plaque structure? - answer✔The aggregation of the different leukocytes

and smooth muscle cells in an ECM that includes collagen and elastic fibers result in the

collagen cap that isolates cholesterol known as the fibrous plaque


fibrous plaque - answer✔Smooth muscles cells proliferate, produce collagen and migrate over a

fatty streak


What is an unstable plaque? - answer✔A plaque that has a large lipid core and a thin cap, and

can rupture more readily, producing a thrombus


What are the clinical manifestations of atherosclerosis? - answer✔1. Narrowing and obstruction

of blood vessels, and formation of blood clots

2. Aneurysms

*manifestations do not become evident for 20-40 years or longer*


What is an aneurysm? - answer✔a localized weak spot or balloon-like enlargement (dilation) of

the three layers of the wall of an artery


What are the two causes of aneurysms? - answer✔1. Atherosclerosis; erodes and weakens the

wall

2. Hypertension; increases wall stress


What are the clinical manifestations of aneurysms? - answer✔They are usually *asymptomatic*

until they *rupture* which is the worst complication

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