100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
Previously searched by you
Previously searched by you
logo
Exam 1: NURS 615/ NURS615 (Latest 2024/ 2025 Update) Advanced Pharmacotherapeutics Complete Guide |Qs & As| 100% Correct| Grade A (Verified Answers) - Maryville $10.99
Add to cart
Quickly navigate to
Preview
  2.  
  3. NURS 615/ NURS615
  4.  
  5. NURS 615/ NURS615

Exam (elaborations)

Exam 1: NURS 615/ NURS615 (Latest 2024/ 2025 Update) Advanced Pharmacotherapeutics Complete Guide |Qs & As| 100% Correct| Grade A (Verified Answers) - Maryville
 0 purchase
  • Course
  • NURS 615/ NURS615
  • Institution
  • NURS 615/ NURS615

Exam 1: NURS 615/ NURS615 (Latest 2024/ 2025 Update) Advanced Pharmacotherapeutics Complete Guide |Qs & As| 100% Correct| Grade A (Verified Answers) Q: Explain first pass metabolism Answer: much of the drug is lost in the absorption process. The liver metabolizes many drugs, thus reduces t...

[Show more]

Preview 4 out of 34  pages

Document information

  • September 30, 2024
  • 34
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

Subjects

  • nur
  • nurs 615nurs615 latestnurs 615nurs
  • exam 1 nurs 615 nurs615 latest updat
  • when 2 drugs are both metabolized by the p450 syst
  • explain first pass metabolism
  • nurs 615nurs615nurs 615 nurs615 final exam

Written for

  • NURS 615/ NURS615
  • NURS 615/ NURS615

Seller

avatar-seller
nurse_steph

Reviews received

Content preview

ExamI1:INURSI615/INURS615I(LatestI2024
/I2025IUpdate)IAdvancedI
PharmacotherapeuticsICompleteIGuideI|QsI
&IAs|I100%ICorrect|IGradeIAI(VerifiedI
Answers)
Q:IExplainIfirstIpassImetabolism

Answer:
muchIofItheIdrugIisIlostIinItheIabsorptionIprocess.ITheIliverImetabolizesImanyIdrugs,IthusIred
ucesItheIbio-availabilityIofItheIdrug.




Q:IWhatIisItheIfastedIrouteIofIabsorption:

Answer:
TheIfastestIrouteIofIabsorptionIisIinhalation,IandInotIasImistakenlyIconsideredItheIIVIadminist
ration.




Q:IWhyIdoesItheIGIItractItakeIlongerItoIabsorb?

Answer:
TheIGIItractIisIlinedIwithIepithelialIcells;IdrugsImustIpermeateIthroughItheseIcellsIinIorderItoI
beIabsorbedIintoItheIcirculatoryIsystem.




Q:IWhatIisIOneIparticularIcellularIbarrierIthatImayIpreventIabsorptionIofIaIgivenIdrug?

,Answer:
theIcellImembrane.ICellImembranesIareIessentiallyIlipidIbilayersIwhichIformIaIsemipermeable
Imembrane.IPureIlipidIbilayersIareIgenerallyIpermeableIonlyItoIsmallIandIunchargedIsolutes,Ih
enceIwhetherIorInotIaImoleculeIisIionizedIwillIaffectIitsIabsorption,IsinceIionicImoleculesIareI
charged.




Q:IWhatIisIsolubility?

Answer:
SolubilityIfavorsIchargedIspecies,IpermeabilityIfavorsIneutralIspecies.ISomeImoleculesIhaveIsp
ecialIexchangeIproteinsIandIchannelsItoIfacilitateImovementIfromItheIlumenIintoItheIcirculatio
n.




Q:IWhyIdoesIabsorptionIoccurIatIaIslowerIrateIforIoral,IIM,ISQIroutes?

Answer:
AbsorptionIoccursIatIaIslowerIrateIbecauseItheIcomplexImembraneIsystemsIofIGIImucosalIlay
ers,Imuscle,IandIskinIdelayIdrugIpassage.




Q:ITheIabilityIofIaIdrugItoIcrossIaIcellImembraneIdependsIon:

Answer:
whetherItheIdrugIisIwaterIorIlipidI(fat)Isoluble.ILipid-
solubleIdrugsIeasilyIcrossIthroughIcellImembranes;Iwater-solubleIdrugsIcan't.ILipid-
solubleIdrugsIcanIalsoIcrossItheIblood-brainIbarrierIandIenterItheIbrain.




Q:IAsIaIdrugItravelsIthroughItheIbody,IitIcomesIinIcontactIwith?

Answer:

,proteinsIsuchIasItheIplasmaIproteinIalbumin.ITheIdrugIcanIremainIfreeIorIbindItoItheIprotein.I
TheIportionIofIaIdrugIthat'sIboundItoIaIproteinIisIinactiveIandIcan'tIexertIaItherapeuticIeffect.I
OnlyItheIfree,IorIunbound,IportionIremainsIactive.IAIdrugIisIsaidItoIbeIhighlyIprotein-
boundIifImoreIthanI80%IofItheIdrugIisIboundItoIprotein.




Q:IIdentifyIdrugImetabolismIandItheIroleIofIisoenzymesIinItheIp450Isystem

Answer:
CYPsIareItheIareItheImajorIenzymesIinvolvedIinIdrugImetabolismIaccountingIforIaboutI75%Io
fItheItotalImetabolism.




Q:INaturallyIoccurringIcompoundsImayIinduceIorIinhibitICYPIactivity.

Answer:
ForIexample,IbioactiveIcompoundsIfoundIinIgrapefruitIjuiceIandIsomeIotherIfruitIjuicesIinclud
ingIdihydroxyIforgottenIandIparasitinIAIhaveIbeenIfoundItoIinhibitICYP3a4ImediatedImetabol
ismIofIcertainImedicationsIleadingItoIincreasedIbioavailabilityIandItheIstrongIpossibilityIofIov
erdosing.




Q:IWhatIdoesIgrapefruitIhaveItoIdoIwithICYP?

Answer:
GrapefruitIisIanIinhibitorIandIwillIdecreaseItheImetabolismIofIdrugsIbyItheIcypIenzymes




Q:IWhenI2IdrugsIareIbothImetabolizedIbyItheIp450IsystemItheIdrugIshouldIbe

Answer:

, administeredIatIseparateItimesItoIpreventItheImetabolismIofIoneIdrugIresultingIinItoxicIeffects
IofItheIotherIdrug.I(becauseIitIwouldIhaveIlessIproteinItoIbindItoo,IthusImoreIfreeIfloatingIdru
g)




Q:IWhatIisItheIefficacyIofIaIdrug?

Answer:
EfficacyIisItheImaximumIresponseIachievableIfromIaIdrug.IEffectivenessIrefersItoItheIabilityIo
fItheIdrugItoIproduceIaIbeneficialIeffect.




Q:IOnItheIdrugIconcentrationIcurveIwhatIisItheIfirstIsignIofIaItherapeuticIeffect?

Answer:
TheIonsetIofIaction




Q:IWhatIisItheIpurposeIofIaIpeakIandItroughIlevel?

Answer:
ToIdetermineIifItheIdrugIisIinItherapeuticIrange.




Q:IDescribeItheIpurposeIofIbloodIbrainIbarrier

Answer:
TheIBBBIisIaIhighlyIselectiveIpermeabilityIbarrierIthatIseparatesItheIcirculatingIbloodIfromIth
eIbrainIandIextracellularIfluidIinItheICNS.ITheIBBBIisIformedIbyIbrainIendothelialIcellsIwhic
hIareIconnectedIbyItightIjunctionsIwithIanIextremelyIhighIelectricalIresistivityIofIatIleastI0.1I
micron.ITheIBBBIallowsItheIpassageIofIwater,IsomeIgases,IandIlipidIsolubleImoleculesIbyIpas
siveIdiffusionIasIwellIasItheIselectiveItransportImoleculesIsuchIasIglucoseIandIaminoIacidsItha
tIareIcrucialItoIneuroIfunction.

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller nurse_steph. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for $10.99. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

69052 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy study notes for 15 years now

Start selling
$10.99
  • (0)
Add to cart
Added