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Ch. 17: Fatty acid catabolism Questions and Answers
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Ch. 17: Fatty acid catabolism Questions and Answers What are the enzymes and compounds of the carnitine shuttle system in fatty acid oxidation? In the cytysol: carnitine --> acyl-carnitine via CAT1 Acyl-carnitine crosses mitochondria membrane to matrix via CAT In the mitochondria matrix: acy...

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  • September 30, 2024
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  • 2024/2025
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  • ch 17 fatty acid catabolism questions and answer
  • what are the enzymes and compounds of the carnitin
  • what is the first reaction of the beta oxidation p

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Ch. 17: Fatty acid catabolism Questions
and Answers

What are the enzymes and compounds of the carnitine shuttle system in fatty acid
oxidation? - answer In the cytysol: carnitine --> acyl-carnitine via CAT1
Acyl-carnitine crosses mitochondria membrane to matrix via CAT
In the mitochondria matrix: acyl-carnitine --> carnitine via CAT2
Carnitine crosses membrane to cytosol via CAT

What is the first reaction of the beta-oxidation pathway? - answer Acyl-CoA
dehydrogenase converts acyl-CoA to trans, alpha-beta, enoyl CoA. The enzyme
prosthetic group is FAD.

What is the second reaction of the beta-oxidation pathway? - answer Enoyl CoA
hydratase converts trans-alpha-beta-enoyl CoA to L-beta-hydroxylacyl-CoA

What is the third reaction of the beta-oxidation pathway? - answer Beta-hydroxyacyl-
CoA dehydrogenase converts L-beta-hydroxylacyl-CoA to beta-ketoacyl-CoA. The
enzyme prosthetic group is NAD+.

What is the fourth reaction of the beta-oxidation pathway? - answer Thiolase
converts beta-ketoacyl-CoA to two acyl CoA molecules, one of them being acetyl CoA.

What happens to an acyl-CoA structure after beta oxidation pathway is complete? -
answer An acetyl-CoA forms. The resulting acyl CoA is two carbons shorter.

Calculate the number of repetitions of the beta-pathway required to fully convert 18-
carbon activated fatty acid to acetyl CoA molecules. - answer 8 repetitions. 18
carbons divided by two minus two results in 8.

Calculate the number of acetyl-SCoA molecules generated by a complete beta
oxidation of a 18-carbon activated fatty acid. - answer 9 acetyl-CoA molecules. (18
carbons divided by two carbons per molecule yield 9 molecules)

Calculate the number of ATPs generated from one saturated 12-C fatty acid. - answer
78 ATP (6(10)+5(2.5)+5(1.5)-2)=78 ATP

Which of the following statements are true about the beta-oxidation pathway of un-
saturated, odd chain fatty acids? - answer Even chained saturated fatty acids are
oxidized to acetyl-CoA in the beta-oxidation pathway.
Complete catabolism of the 3-C remnant of a 15-C fatty acid requires some citric acid
cycle enzymes

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