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BCEM 547 MIDTERM 1 QUESTIONS WITH COMPLETE SOLUTIONS
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BCEM 547 MIDTERM 1 QUESTIONS WITH COMPLETE SOLUTIONS
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BCEM 547 MIDTERM 1 QUESTIONS WITH COMPLETESOLUTIONS
_________ constitute the single largest protein superfamily
encoded by animal genomes and are the number one drug target
of the pharmaceutical industry Correct Answer GCPRs
__________ different MAPKKKs, _______different MAPKKs
& ____________ different MAPKs identified in mammals.
Correct Answer 14
7
13
____________ (AC) catalyzes the synthesis of ________ from
________ Correct Answer Adenylate cyclase
cAMP
ATP
_______________ is 1 of the 2 most frequently mutated
pathway of human cancer(s). Correct Answer PI3Ka
__________and____________ were also the founding members
of the PI kinase-related protein kinase (PIKK) family of ser/thr-
specific kinases (other members include ATM, DNA- PK,
TRRAP and ATR). Correct Answer TOR1 and TOR2
_____,_______ and _________ are related in sequence (PPP
family). Correct Answer PP1, PP2A and PP2B
(PI metabolism) The phosphoinositide kinases that catalyse the
addition of phosphate groups to the 3-, 4- and/or 5-positions are
,shown, as are the lipid phosphatases ___________ and
_____________ Correct Answer PTEN
SHIP
•__________________ comprise ~2-3%of the protein-encoding
portion of the genome in most eukaryotes. Correct Answer
Protein kinases
•258 out of 518 kinases have ______________________
Correct Answer additional protein domains
•Arrestins form a small group of proteins that bind GPCRs &
compete for binding with heterotrimeric G proteins —> thus,
arrestin binding prevents ______________________________
Correct Answer further activation of additional G proteins.
•Blocking PP2B function inhibits the signaling cascade and T-
cells do not
.............................................., thus no immune response Correct
Answer dephosphorylate
•Class III PI3K-generated PtdIns3P represents a major
regulatory pathway defining and controlling the passage of
proteins and membranes through the Correct Answer
endosomal/lysosomal compartments.
•FK506 binds another protein, _________________, and the
FK506-FKBP12 complex inhibits _________________.
Correct Answer FKBP12
PP2B
,•Human protein kinases are divided into 8 major groups:
Correct Answer AGC
CaMK
CK1/2
CMGC
PTK
PTKL
STE
other (not in major group)
•Protein kinases have two domains - Correct Answer the N-
domain and C-domain.
•Protein phosphatases are different from protein kinases because
they _____________________________________. Correct
Answer do not dephosphorylate at well-defined sequences
1.By utilizing different members of these protein families,
mammals can assemble a number of different
______________________ that transmit
______________________________ Correct Answer MAP
kinase pathways
different types of extracellular signal.
1.Ras has a function similar to that of
_______________________ discussed before; Ras acts like a
molecular ______________; unlike heterotrimeric G proteins,
Ras consists of only a ______________ small subunit. Correct
Answer heterotrimeric G proteins
timer
single
, 1000s of proteins are acetylated on ____ Correct Answer K
2 forms of glycogen phosphorylase (interconvertible)
pg.11 Correct Answer phosphorylase a (active in absence of
5'AMP)
phosphorylase b (active with high concentrations of 5' AMP)
83 different domains characterized including: Correct Answer -
25 with PH domains
-23 with SH2 domains
A fourth family utilizes Asp-based catalysis Correct Answer
FCP/SCP dephosphorylates 3 serines on RNA-polymerase II.
Phosphorylation of 52 heptad repeats of YpS2TpS5pS7 of
human Pol II CTD at Ser2, Ser5, and Ser7 involves multistep
transcriptional regulation.
A molecular switch is _______ and _______ Correct Answer
fast and cheap
A molecular switch is usually flipped by a _____________ of
the target protein Correct Answer covalent modification
A number of inherited disorders have been traced to defects in
both _____ and _________. Correct Answer GPCRs &
heterotrimeric G proteins.
A number of other 2nd messengers have been found in
eukaryotic cells: Correct Answer Ca2+ ions,
phosphoinositides,
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