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WGU D116 UNIT 2 QUESTIONS AND ANSWERS
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WGU D116 UNIT 2 QUESTIONS AND ANSWERS
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WGU D116 UNIT 2 QUESTIONS AND ANSWERSA patient receives a drug that has a narrow therapeutic range. What is the nurse
administering this medication expected to do?
A. Monitor plasma drug levels.
B. Administer the drug at intervals longer than the drug half-life.
C. Teach the patient that maximum drug effects will occur within a short period.
D. Administer this medication intravenously
A. Monitor plasma drug levels
A drug with a narrow therapeutic range is more difficult to administer safely because the
difference between the minimum effective concentration (MEC ) and the toxic
concentration is small. Patients taking these medications must have their plasma drug
levels monitored closely to ensure that they are getting an effective dose that is not
toxic.
A patient is receiving intravenous gentamicin. A serum drug test reveals toxic levels.
The dosing is correct, and this medication has been tolerated by this patient in the past.
What is a probable cause of the test result?
A. The drug was not completely dissolved in the IV solution.
B. A loading dose was not given.
C. The medication is being given at a frequency that is longer than its half-life.
D. The patient is taking another medication that binds to serum albumin.
D. The patient is taking another medication that binds to serum albumin.
Correct! Gentamicin binds to albumin, but only weakly. In the presence of another drug
that binds to albumin, gentamicin can rise to toxic levels in blood serum.
What are the components of pharmacokinetics?
Absorption, distribution, metabolism, excretion
, Does the volume of distribution increase or decrease as the concentration of a drug in
the blood plasma increases?
DECREASES
A patient reports becoming "immune" to a medication because it no longer works to
alleviate symptoms.
The provider recognizes that this decreased effectiveness is likely caused by what?
A. synthesis of more receptor sites in response to the medication
B. decreased selectivity of receptor sites, resulting in a variety of effects
C. desensitization of receptor sites by continual exposure to the drug
D. antagonists produced by the body that compete with the drug for receptor sites
C. Desensitization of receptor sites by continual exposure to the drug
Continual exposure to an agonist would cause the cell to become less responsive or
desensitized
What occurs when a drug binds to a receptor in the body?
A. It increases or decreases the activity of that receptor.
B. It alters the receptor to become nonresponsive to its usual endogenous molecules.
C. It prevents the action of the receptor by altering its response to chemical mediators.
D. It gives the receptor a new function.
A. It increases or decreases the activity of that receptor
Correct! When a drug binds to a receptor, it mimics or blocks the actions of the usual
endogenous regulatory molecules, either increasing or decreasing the rate of the
physiologic activity normally controlled by that receptor.
Which pharmacodynamic principle is most correlated with drug toxicity?
A. Therapeutic index
B. Intrinsic activity
C. Competitive antagonists
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