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NR 577 final Questions And Answers
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NR 577 final Questions And Answers...
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NR 577 final Questions And AnswersMore likely to cause hypoglycemia
Insulin, Sulfonylureas, Meglitinides, Amylin analogues
Less likley to cause hypoglycemia
Incretin mimetics, Metformin, Thiazolidneidiones, DPP-4 inhibitors
Biguanides
metformin
GLP-1
ozempic, trulicity, vitoza
SGLT2-I
Invokana, farxiga, jardiance
DPP-4i
Januvia, onglyza, tradjenta, nesina
Thiazolinidenoiones
Avandia, actos
Sulfonylurea
glyburide, glipizide, glimerpride
Rapid acting insulin
Humalog( Lispro)
Novalog (Aspart)
Apidra
Rapid acting insulin
onset 5-30 minutes duration 3-4hrs
Short acting insulin
, Regular (Humulin R or Novalin R)
Short acting insulin onset
30-60 minutes duration 3-7hrs
Intermediate acting insulin
NPH or Humulin N
Long acting insulin
Lantus, levimir
Fixed combination insulin
NPH/Reg 70/30, 50/50, 75/25, 70/30
Hypothyrodisim and skin
Thick course dry skin
Hyperthryodism and skin
smooth silky
Drug of choice for DM2
metformin
MOA of metformin
enhance tissued responsiveness to insulin. They are also less likely to cause
hypoglycemia and help tx insulin resistance. Metformin facilitates insulin uptake by
peripheral tissue esp muscle and liver and decrease hepatic gluconeogenesis and basal
glucose output thus lowering fasting glucose levels.
Dosing of metformin
Starting 500mg QD then after one week 500mg BID then increase slowly over 1-2 wks
before your at max dose between 2000-2500mg/QD
Sulfonylureas (Glyburide, glipizide, glimepridie) MOA
acutley increase the sensitivity of beta cells to gluocse and stimulate endogenous
insulin release. This can lead to hypoglycemia
Dosing of glyburide
2.5mg BID
dosing of glipizide
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