•1 in 5 patients with intracranial tumors present with pituitary tumor
Growth Hormone (GH; hGH)
•Primary function = regulation of growth in childhood and puberty Adrenocorticotropic
Hormone (ACTH)
•Primary function = to regulate release of cortisol & other corticosteroids, & androgens
•Pituitary ACTH is signaled by hypothalamus by corticosteroid releasing hormone (CRH)
•Plays an important role in augmenting metabolism and euvolemic fluid balance
•cortisol & glucocorticoids 1) increase blood sugar, 2) induce catabolism of proteins
and fats 3) cause bone resorption
, •mineralocorticoids cause sodium reclamation from the nephrons à 'where salt goes,
water will follow'
•Androgens help increase muscle and bone mass, play critical role in male 2nd sex
characteristics
•Also, spermatogenesis and testicular development
•Testicular androgen production
Thyroid Stimulating Hormone Thyrotropin; TSH
•Primary function is to control the release of thyroxine T4 from thyroid
•To a lesser degree, triiodothyronine T3
•Negative feedback loop between thyroid release hormone TRH, TSH, and ultimately- T4
•TSH is not an 'active thyroid hormone'; T4 and T3 are
•As more TSH binds to TSH receptors in the thyroid, more active thyroid hormone is
released
•~80% as T4
•~20% as T3
•Iodine intake and utilization is necessary for normal thyroid and thyrotropic function
Follicle Stimulating Hormone &Luteinizing Hormone
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