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Questions and answers for HTHSCI 3I03: B Cell Development
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Questions and answers for HTHSCI 3I03: B Cell Development
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1-41 of 411. Chemokine CCL21 attracts immature B cells to HEV
2. Chemokines CCL21 and CCL19 attract B cells into lymph node
3. Chemokine CXCL13 attracts B cells into the primary follicle
4. Interactions with follicular dendritic cells and cytokines drives the maturation of
immature B cells
5. Mature B cells recirculate between lymph, blood, and secondary lymphoid tissues
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, Steps in B cell positive selection (5 - specific)
Fighting the current infection
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Antibody-secreting plasma cell
IgM of immature B cell binds to soluble univalent self antigen. The B cell is signalled
to make IgD and to become unresponsive to antigen, and then enters the peripheral
circulation but does not survive for long.
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How does an anergic B cell develop?
1. Stem cell: u germline
2. Early pro-B cell: u germline, κ/λ germline
3. Late pro-B cell: uDJ, κ/λ germline
4. Large pre-B cell: uVDJ, κ/λ germline
5. Small pre-B cell: uVDJ, κ/λ germline
6. Immature B cell: uVDJ, κ/λ VDJ
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Cell types in B cell development: bone marrow
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