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all of the questions on the HTHSCI 3I03 Final Exam have the correct answers
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all of the questions on the HTHSCI 3I03 Final Exam have the correct answers
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1-171 of 171What happens in the absence of microbiota?
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- immune development doesn't occur normally
- Smaller spleen, reduction in IgA and T killer cells
,What is original antigenic sin?
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- Unable to produce antibodies to antigens of flu when other antigens
have remained the same
- virus gradually escapes immune response
Why do short-lived plasma cells die and long-lived ones survive?
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- survival is maintained by interaction with stromal cells of the bone-
marrow and IL-6
- short-lived plasma cells due as a result of inhibitory mechanisms
- antigen/antibody complexes bind Fc-gamma-RIIB1 and induce plasma
cell apoptosis
- loss of contact results in loss of survival signals
What is the main effect of Mtb imposed innate immune suppression?
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- retarded dendritic cell transmigration to dLN
- takes 10-14 days
,How does the concentration and affinity of antibodies (IgM vs IgG) change after
vaccinations
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- Amount of IgG increases with each vaccination
- affinity of IgG increases with each vaccination
- Amount of IgM increases after first vaccination and then decreases and
levels off
- Affinity of IgM only very mildly increases
What can BCRs do that TCRs can't?
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- isotype switching
- somatic hypermutation
- transition from membrane to soluble form
What is mucin?
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, - secreted into mucosal membranes
-many other molecules can attach to it
- can form a sticky barrier to prevent pathogen adhesion
- can also bind IgA
- different mucosal tissues produce different mucins
- some are secreted and some are membrane bound
How does IgA remove toxins from lamina propria?
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- bind toxins in lamina propria and take them with them when IgA is
secreted
- IgA is most commonly in dimeric form
What is the second stargety the mucosal immune system has to avoid peritonitis?
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- spare activation of inflammation
- less tissue damage
- Treg cells turn off inflammatory T-cells and produce IL-10 to suppress
inflammation (stops transcription of inflammatory cytokines)
How many people are effected by TB?
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