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NMTCB PET certification Review UPDATED Actual Questions and CORRECT Answers

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NMTCB PET certification Review UPDATED Actual Questions and CORRECT Answers Rb-82 Genertaor Alert Level - CORRECT ANSWER- 14L of eleute volume reached, or Sr-82 level 0.002uCi/mCi of Rb-82, or Sr-85 level 0.02uCi/mCi of Rb-82 Actions for Rb82 Generator Alert Level - CORRECT ANSWER- Test afte...

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NMTCB PET certification Review
UPDATED Actual Questions and
CORRECT Answers
Rb-82 Genertaor Alert Level - CORRECT ANSWER✔✔- 14L of eleute volume reached, or
Sr-82 level 0.002uCi/mCi of Rb-82, or Sr-85 level 0.02uCi/mCi of Rb-82

Actions for Rb82 Generator Alert Level - CORRECT ANSWER✔✔- Test after every 750
mL has passed through generator

Stop using Rb-82 generator if - CORRECT ANSWER✔✔- 17L of eleute volume reached, or
42 days post calibration date, or Sr82 levenis 0.01uCi/mCi of Rb82, or Sr85 level reaches
0.1uCi/mCi of Rb82

Cyclotron produced isotopes and half-life - CORRECT ANSWER✔✔- C11, 20.3 min; N13
9.97 min; O15 2.03 min; F18, 109.7 min

Advantages of negative ion cyclotrons - CORRECT ANSWER✔✔- 1) less nuclear
activation of cyl potion cavity and surroundings, 2) can self-focus beam of particles, 3) can
irradiate 2 targets at once

Isotopes produces by negative ion cyclotrons - CORRECT ANSWER✔✔- C, N, O =
metabolites

Reaction for chemical labeling of F18-FDG - CORRECT ANSWER✔✔- Nucleophilic
substitution

Chemical reaction of FDG - CORRECT ANSWER✔✔- Electron rich group of atoms change
place on molecule with a positively charged leaving group

Precursor molecule for FDG - CORRECT ANSWER✔✔- Mannose triflate

,Chem formula of FDG - CORRECT ANSWER✔✔- 2-deoxy-2-[18F]fluoro-D-glucose.
(Fludeoxyglucose F-18)

Intermediate step in FDG synthesis - CORRECT ANSWER✔✔- Alkaline hydrolysis of 4
acetyl groups by replacing with OH

Size filter used after purification - CORRECT ANSWER✔✔- 0.22 um

FDA ref for PET pharma production - CORRECT ANSWER✔✔- General chapter 823

FDG QA appearance - CORRECT ANSWER✔✔- Colorless liquid

FDG QA radiochemical identity - CORRECT ANSWER✔✔- Thin-layer chromatography Rf
value to reference standard

FDG QARadionuclide identity - CORRECT ANSWER✔✔- Half-life 105 and 115 minutes

FDG QA bacterial endotoxins test - CORRECT ANSWER✔✔- LAL (Limulus amebocyte
lysate) <175 USP endotoxins units per max volume injection; endotoxins< 17.5 EU

FDG QC pH - CORRECT ANSWER✔✔- Between 4.5 to 7.5

FDG QA Radiochemical purity - CORRECT ANSWER✔✔- Thin-layered chromatography
radioactive Rf should be not less than 90% of total radioactivity of chromatography plate

FDG QC Radionuclideic purity - CORRECT ANSWER✔✔- should be >99.5% of
radionuclidie specified. tested using multi-channel analyzer with peaks at 0.511 and 1.022
MeV

FDG QC chemical purity - CORRECT ANSWER✔✔- testing depends upon synthesis
method used to create FDG

, Kryptofix 222 - CORRECT ANSWER✔✔- FDG QC chemical purity test - thin-layer paper
chromatography spot test. 50 ug/mL and FDG solution must demonstrate a less intense
response than standard

2-Chloro-2-deoxy-D-glucose - CORRECT ANSWER✔✔- FDG QC chemical purity test
used if hydrolysis step was performed with hydrochloric acid. Use high-performance liquid
chromatography using an electrochemical detector. Mus not have more than 1 mg CLDG: 2-
deoxy-2-D-glucose

FDG QC Residual solvents - CORRECT ANSWER✔✔- solvents can be in FDG from
cleaning or synthesis solutions. solutions may contain acetonitrle, ether anddehydrated
alcohol. no more 0.04% acetonitrle, and less than 0.5% of ether or ethanol

FDG QC Sterility - CORRECT ANSWER✔✔- not performed before dosing due to need of
14 days to perform. Regulations require final produce to be placed in soy broth mixture with
a thioglycollate growth media for 30 hrs. look for observable bacteria

FDG QC Filter membrane integerity - CORRECT ANSWER✔✔- final sterility filter used at
end of manufacturing process. Filter must remain intact as pressure increased to 50 psi
(bubble point test)

FDG synthesis room requirements - CORRECT ANSWER✔✔- room: cGMP, ISO class 5
clean room air hood, 21 CFR 212 for manufacturing of IV drugs

which radiouclides are possible radioactive contaminates in eluent of Rb82 generators -
CORRECT ANSWER✔✔- Sr82 and Dr85

negative ion PET cyclotrons accelerate which partiles - CORRECT ANSWER✔✔-
negatively charged hydrogen atoms

chemical method used to label F18 to glucose - CORRECT ANSWER✔✔- nucleophilic
substitution

The least amount of energy needed by bombarding particles used for nuclear reactions
occurring within a cycltron - CORRECT ANSWER✔✔- 8 Mev

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