10/4/24, 7:08 PM NURS 615 PHARM EXAM 1 – MARYVILLE ACTUAL EXAM 2024 EXAM COMPLETE MOST TESTED QUESTIONS WITH DE…
NURS 615 PHARM EXAM 1 – MARYVILLE
ACTUAL EXAM 2024 EXAM COMPLETE MOST
TESTED QUESTIONS WITH DETAILED VERIFIED
ANSWERS (100% CORRECT ANSWERS)
/ALREADY GRADED A+ GET IT 100% CORRECT
Terms in this set (147)
How does Low albumin = more free drug (bc the drug can't
hypoalbuminemia affect bind to albumin aka protein) = increased adverse
the process of effects
prescribing?
What is a Black Box is considered a contraindication to administer that
Warning: drug.
Half-life specifically means the amount of time it
What is the drugs half-
takes for an administered drug to be halfway
life?
cleared from the system.
the time between drug administration and maximum
Peak of action: concentration of drug in the blood stream. Best
therapeutic effect.
the time between onset of action and metabolism of
Duration of action: drug below the minimum needed for an effect. The
length of time you have the drug in your system.
According to the WHO The first step is to define the patient's problem
what is the first step in
the prescribing process?
The second step is to specify the therapeutic objective
The third step is to choose which drug or treatment is needed.
,10/4/24, 7:08 PM NURS 615 PHARM EXAM 1 – MARYVILLE ACTUAL EXAM 2024 EXAM COMPLETE MOST TESTED QUESTIONS WITH DE…
Step 4 of the WHO Start the treatment
approach:
Step 5 of the WHO Educate the patient
approach:
Step 6 of the WHO Monitor the treatment
approach:
Phase 1 of drug The drug is tested on healthy volunteers
development:
Phase 2 of drug trials with people who have the disease for which
development: the drug is thought to be effective
Large numbers of patients in medical research
centers receive the drug in phase 3. This larger
Phase 3 of drug
sampling provides information about infrequent or
development:
rare adverse effects. The FFA will approve a new
drug application if phase 3 studies are satisfactory.
This phase is voluntary and involves postmarket
surveillance of the drug's therapeutic effects at the
completion of phase 3. The pharmaceutical
company receives reports from doctors and other
Phase 4 of drug
health care professionals about the therapeutic
development:
results and adverse effects of the drug. Some
medications, for example, have been found to be
toxic and have been removed from the market after
their initial release.
much of the drug is lost in the absorption process.
Explain first pass
The liver metabolizes many drugs, thus reduces the
metabolism
bioavailabilty of the drug.
What is the fasted route The fastest route of absorption is inhalation, and not
of absorption: as mistakenly considered the IV administration.
The GI tract is lined with epithelial cells; drugs must
Why does the GI tract
permeate through these cells in order to be
take longer to absorb?
absorbed into the circulatory system.
, 10/4/24, 7:08 PM NURS 615 PHARM EXAM 1 – MARYVILLE ACTUAL EXAM 2024 EXAM COMPLETE MOST TESTED QUESTIONS WITH DE…
the cell membrane. Cell membranes are essentially
lipid bilayers which form a semipermeable
What is One particular
membrane. Pure lipid bilayers are generally
cellular barrier that may
permeable only to small and uncharged solutes,
prevent absorption of a
hence whether or not a molecule is ionized will
given drug?
affect its absorption, since ionic molecules are
charged.
Solubility favors charged species, permeability
favors neutral species. Some molecules have special
What is solubility?
exchange proteins and channels to facilitate
movement from the lumen into the circulation.
Why does absorption Absorption occurs at a slower rate because the
occur at a slower rate for complex membrane systems of GI mucosal layers,
oral, IM, SQ routes? muscle, and skin delay drug passage.
whether the drug is water or lipid (fat) soluble.
The ability of a drug to Lipid-soluble drugs easily cross through cell
cross a cell membrane membranes; water-soluble drugs can't. Lipid-soluble
depends on: drugs can also cross the blood-brain barrier and
enter the brain.
proteins such as the plasma protein albumin. The
drug can remain free or bind to the protein. The
As a drug travels through portion of a drug that's bound to a protein is
the body, it comes in inactive and can't exert a therapeutic effect. Only
contact with? the free, or unbound, portion remains active. A drug
is said to be highly protein-bound if more than 80%
of the drug is bound to protein.
Identify drug metabolism CYPs are the are the major enzymes involved in
and the role of drug metabolism accounting for about 75% of the
isoenzymes in the p450 total metabolism.
system
For example, bioactive compounds found in
grapefruit juice and some other fruit juices including
Naturally occurring dihydroxy forgotten and parasitin A have been
compounds may induce found to inhibit CYP3a4 mediated metabolism of
or inhibit CYP activity. certain medications leading to increased
bioavailability and the strong possibility of
overdosing.
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