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HOSA Pharmacology Exam Study Guide with Complete Solutions

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HOSA Pharmacology Exam Study Guide with Complete Solutions Absorption - Answer-Process by which a drug enters the circulatory system (blood). Intravenous (IV) & Intra-Arterial - Answer-Administration/Dosage routs that do not require absorption. Absorption, Distribution, Metabolism, & Eliminati...

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HOSA Pharmacology Exam Study Guide
with Complete Solutions
Absorption - Answer✔✔-Process by which a drug enters the circulatory system (blood).


Intravenous (IV) & Intra-Arterial - Answer✔✔-Administration/Dosage routs that do not require

absorption.


Absorption, Distribution, Metabolism, & Elimination... The Pharmacokinetic Process - Answer✔✔-ADME


Addiction - Answer✔✔-Dependence characterized by a perceived need to take a drug to attain the

psychological & physical effects of mood altering substances.


Affinity - Answer✔✔-Natural attraction - the strength by which a particular chemical messenger binds to

its receptor site on a cell


Agonist - Answer✔✔-Drug that mimics the action of a neurotransmitter when it binds to a particular

receptor site - i.e. & triggers the cell's response in a manner similar to the action of the body's own

chemical messenger.


Allergen - Answer✔✔-Substance of a usually harmless nature that produces an abnormal hypersensitive

reaction.


Allergic Response - Answer✔✔-A hypersensitive reaction to any usually harmless substance that does

not normally cause a reaction.




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Anaphylactic Reaction - Answer✔✔-Severe allergic response resulting in immediate life-threatening

respiratory distress, usually followed by vascular collapse & shock accompanied w/ hives.


Angioedema - Answer✔✔-Abnormal accumulation of fluid in tissue.


Antagonist - Answer✔✔-Drug that neutralizes or counteracts the effects of a neurotransmitter or

another drug when it binds to a particular receptor site.


Antigen - Answer✔✔-Foreign substance that is recognized by the immune system & induces the immune

system to produce antibodies to defend against the foreign substance.


Bioavailability - Answer✔✔-Degree to which a drug or other substance becomes available to the target

tissue after administration.


Blood-Brain Barrier - Answer✔✔-Fortified area that prevents many substances from entering the

cerebro-spinal fluid from the blood. This area is formed by glial cells that envelope capillaries in the

fcentral nervous system. This creates a shield that blocks many water-soluble compounds, but is

permeable to lipid-soluble substances.


Ceiling Effect - Answer✔✔-Point @ which no clinical response occurs w/ increased dosage of a drug.


Clearance - Answer✔✔-Rate @ which a drug is eliminated from a specific volume of blood per unit of

time.


Contraindication - Answer✔✔-Any disease, condition, or symptom for which a drug will not be beneficial

& may be harmful.


Dependence - Answer✔✔-State in which a person's body has adapted physiologically & psychologically

to a drug & cannot function w/o it.

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Distribution - Answer✔✔-Process by which a drug moves from the blood into other body fluids & tissues

& ultimately to its site(s) of action.


Dose - Answer✔✔-Quantity of a drug administered at one time.


Drug Abuse - Answer✔✔-Use of a drug for purposes other than those prescribed &/or in amounts that

were not directed. This is often linked to addiction.


Drug Interaction - Answer✔✔-When a drug is affected in some way by another drug, foods, or other

substances, such as when enzymes that metabolize the drug are induced or inhibited.


Drug Interaction Relationship: Addition - Answer✔✔-The combined effect of 2 drugs is equal to the sum

of the effects of each drug taken alone.


Drug Interaction Relationship: Antagonism - Answer✔✔-The action of 1 drug negates the action of a 2nd

drug.


Drug Interaction Relationship: Potentiation - Answer✔✔-1 drug increases or prolongs the action of

another drug, & the total effect is greater than the sum of the effects of each drug used alone - drug

potency is increased.


Drug Interaction Relationship: Synergism - Answer✔✔-The combined effect of 2 drugs is more intense or

longer in duration than the sum of their individual effects. Drugs that work in combination like this are

usually prescribed together.


Enzymes, Nucleic Acids, Receptors, & Transport Proteins - Answer✔✔-Types of specific body molecules

that drugs can combine w/.




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Duration Of Action - Answer✔✔-Length of time a drug gives the desired response/remains at the

therapeutic level.


Elimination - Answer✔✔-Removal of a drug or the drugs metabolites from the body by excretion.


First-Order - Answer✔✔-Drugs for which the rate of elimination is concentration dependent (as opposed

to ____ _ _____).


First-Pass Effect - Answer✔✔-Extent to which a drug is metabolized by the liver before reaching full body

circulation. This can substantially decrease bioavailability of certain drugs when administered orally, in

which case administration by injection is required.


Half-Life - Answer✔✔-Time necessary for the body to eliminate half of the drug in the body @ any 1

time (written as T 1/2).


Homeostasis - Answer✔✔-Maintenance of stability in the internal environment of the body.


Induction - Answer✔✔-Process by which a drug increases the concentration of certain enzymes that

affect the pharmacologic response to other drugs.


Inhibition - Answer✔✔-Process by which a drug blocks enzyme activity & impairs the metabolism of

another drug.


Interaction - Answer✔✔-Change in the action of a drug caused by another drug, food, or another

substance, such as alcohol or nicotine.


Lipid - Answer✔✔-Fatty molecule - An important constituent of cell membranes; they generally repel

water.



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