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HPRS 2301 Unit 4 Exam Questions and Answers | 100% Pass

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HPRS 2301 Unit 4 Exam Questions and Answers | 100% Pass What is atherosclerosis? - Answer-Hardening of the arteries caused by the formation of fibro-fatty lesion *plaque* within the vessel wall What are the main causes of atherosclerosis? - Answer-1. A genetic component 2. Hypercholesterolemia...

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  • October 5, 2024
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  • HPRS 2301
  • HPRS 2301
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EmillyCharlotte
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HPRS 2301 Unit 4 Exam Questions and
Answers | 100% Pass

What is atherosclerosis? - Answer✔✔-Hardening of the arteries caused by the

formation of fibro-fatty lesion *plaque* within the vessel wall


What are the main causes of atherosclerosis? - Answer✔✔-1. A genetic component

2. Hypercholesterolemia

3. Cigarette smoking, obesity, hypertension and diabetes

Out of the 3 causes for atherosclerosis, which can be considered a *major risk factor*? -

Answer✔✔-Hypercholesterolemia

What is hypercholesterolemia? - Answer✔✔-Excess cholesterol in blood; heart

disease

What are the four steps in the pathogenesis of atherosclerosis? - Answer✔✔-1.

Endothelial cell injury

2. Migration of inflammatory cells

3. Lipid accumulation and smooth muscle cell proliferation

4. Plaque structure

What happens in endothelial cell injury? - Answer✔✔-The endothelial cells that line

the wall of the blood vessel are damaged due to cigarette smoking, elevated LDL,

immune mechanisms, and hypertension




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, EMILLYCHARLOTTE 2024/2025 ACADEMIC YEAR ©2024 ALL RIGHTS RESERVED,
FIRST PUBLISH SEPTEMBER 2024
What does it mean when an individual has elevated LDL - Answer✔✔-The high levels

of *low density proteins* known as *bad cholesterol* result in the buildup of cholesterol

in the arteries

What happens in the migration of inflammatory cells? - Answer✔✔-1. The endothelial

cells release chemicals that attract and bind the cells of the inflammatory response and

monocytes towards the area

2. The endothelial cells also express adhesion molecules that indicate to the

inflammatory cells and monocytes that this is the site where the endothelial cell is

damaged

What happens during lipid accumulation and smooth muscle cell proliferation? -

Answer✔✔-1. Monocytes transform into macrophages and release a chemical that is

based on O2 species that oxidize the LDL, once it becomes oxidized they then ingest

the LDL and transform into *foam cells*

2. Macrophages can also release growth factors that cause the migration and

proliferation of smooth muscle cells, lymphocytes, and fibroblasts

foam cells - Answer✔✔-The characteristic initial lesion of atherosclerosis, also known

as a fatty streak

When do fatty streaks appear? - Answer✔✔-1. May form within the first year of life

2. May increase in numbers by the second decade of life, and remain static or regress

What happens during plaque structure? - Answer✔✔-The aggregation of the different

leukocytes and smooth muscle cells in an ECM that includes collagen and elastic fibers

result in the collagen cap that isolates cholesterol known as the fibrous plaque


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, EMILLYCHARLOTTE 2024/2025 ACADEMIC YEAR ©2024 ALL RIGHTS RESERVED,
FIRST PUBLISH SEPTEMBER 2024
fibrous plaque - Answer✔✔-Smooth muscles cells proliferate, produce collagen and

migrate over a fatty streak

What is an unstable plaque? - Answer✔✔-A plaque that has a large lipid core and a

thin cap, and can rupture more readily, producing a thrombus

What are the clinical manifestations of atherosclerosis? - Answer✔✔-1. Narrowing

and obstruction of blood vessels, and formation of blood clots

2. Aneurysms

*manifestations do not become evident for 20-40 years or longer*

What is an aneurysm? - Answer✔✔-a localized weak spot or balloon-like

enlargement (dilation) of the three layers of the wall of an artery

What are the two causes of aneurysms? - Answer✔✔-1. Atherosclerosis; erodes and

weakens the wall

2. Hypertension; increases wall stress

What are the clinical manifestations of aneurysms? - Answer✔✔-They are usually

*asymptomatic* until they *rupture* which is the worst complication

What is a thrombus? - Answer✔✔-blood clot that remains attached to the vessel wall

What is an embolus? - Answer✔✔-a blood clot that has broken loose and is floating

freely in the blood stream

What is venous thrombosis also known as thrombophlebitis - Answer✔✔-Most

common disorder of the veins and involves the formation of a thrombus (clot) in

association with inflammation of the vein.



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