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NURP-424: Exam 2 Practice Questions and Answers |100% Pass

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NURP-424: Exam 2 Practice Questions and Answers |100% Pass How do phosphodiesterase type 5 (PDE-5) inhibitors work? - Answer-PDE-5 inhibitors work by blocking the catabolism of cyclic GMP which results in an increased number and duration of erections in men with ED. Pharmacokinetics: Pediatric...

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  • October 6, 2024
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NURP-424: Exam 2 Practice Questions
and Answers |100% Pass

How do phosphodiesterase type 5 (PDE-5) inhibitors work? - Answer✔✔-PDE-5 inhibitors work by

blocking the catabolism of cyclic GMP which results in an increased number and duration of erections in

men with ED.


Pharmacokinetics: Pediatrics (2) - Answer✔✔-- Blood brain barrier is incomplete and more permeable




- Small infants have less protein binding capability which leads to more free drug in the body




- Kidneys are not matured so excretion and elimination is slowed




- Skin is thin and more permeable so it absorbs quicker




- Oral bioavailability of weak bases compounds is increased.


( e.g. Beta-lactams)




- Oral bioavailability of weak organic acids is decreased.


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(e.g. Phenobarbital and phenytoin)


Which method of contraception has a Black Box Warning due to causing significant bone mineral density

(BMD) loss in adolescents? - Answer✔✔-Medroxyprogesterone acetate (Depo shot)


A mother asks the APN about using an over-the-counter (OTC) medication for her child because the label

says, "Consult your provider for use instructions as safety and effectiveness have not been established."

Which response by the APN is most appropriate? - Answer✔✔-"Pediatric studies have shown this drug

to be either unsafe or ineffective in children."


Which of these would the APN include in teaching for the transmasculine patient starting testosterone

replacement therapy? - Answer✔✔-The patient's periods should stop within 6 months.


A transfeminine patient is preparing for feminizing hormone therapy. Which of these would the APN

include in teaching about the effects of hormone therapy? - Answer✔✔-It may take months, and even

up to a year, for the patient to see the full effect of the hormones.


Which of these does testosterone replacement therapy (TRT) cause? - Answer✔✔-Decreased fat mass


Normal aging is associated with a decrease in serum albumin levels. How does this impact drug

distribution? - Answer✔✔-Fewer protein molecules are available for drug binding, leading to higher

levels of free, unbound drug and an increased risk for drug toxicity.


Normal age-related changes alter the absorption of medications from the gastrointestinal (GI) tract.

Which of these is caused by age-related changes? - Answer✔✔-Decreased acid production


Which of these is a potential pharmacodynamic difference in children as compared with adults? -

Answer✔✔-Unexpected side effect different than an adult


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Which of these would the APN need to consider when selecting the best option for the patient beginning

testosterone replacement therapy? - Answer✔✔-Injectable testosterone is the least expensive.


The APN knows that children are often at higher risk for ADRs for which two reasons? - Answer✔✔-

Inattention to weight-based dosing and immature organ function in the very young, which makes dosing

more complicated


Which statement regarding topical absorption of medications is accurate? - Answer✔✔-It is increased in

children due to larger body surface in relation to their size.


The APN is following a 68-year-old male who had an acute myocardial infarction (MI) about 4 months

ago. He is not seeing a cardiologist anymore. He is doing well and has returned to all his regular

activities. He is tolerating a low dose beta blocker, which was started after the heart attack. He has never

had any chest pain or exercise intolerance. He has a prescription for sublingual nitroglycerine when

necessary but has never needed it. He requests a refill on his Viagra. Which action taken by the APN is

most appropriate? - Answer✔✔-Tell him he has to wait 6 months after his heart attack to use this

medication again.


Gender Differences: Pharmacodynamics - Answer✔✔-- Opioids have a greater analgesic effects and side

effects in women than men (i.e. N/V)




- Aspirin will lower the risk for stroke but will have little effect if given prophylactically for an MI in

women (the opposite is in men)




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- Warfarin will have less benefit to women and more susceptible to adverse effects such as bleeding




- Tricyclic antidepressants will take longer to reach a steady state and will cause more adverse effects in

women




- Antipsychotics will have better outcomes but more side effects in women




- Medication takes longer to be absorbed due to increased adipose tissue/fat, so bioavailability is higher

in women


Pharmacokinetics in Women - Answer✔✔-- Gastric emptying time is slower d/t estrogen which will give

medications more time at the absorption site




- Plasma concentration of alcohol is greater in females with the same amount of alcohol intake




- Females have a higher proportion of body fat which makes it easier for them to absorb lipophilic drugs




- Women have a harder time with tricyclic antidepressants which makes them more likely to experience

SE




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