NR 566 MIDTERM EXAM (2 LATEST VERSIONS
2023-2024) / NR566 MIDTERM EXAM REVIEW
/LATEST ADVANCED PHARMACOLOGY FOR
CARE OF FAMILY|AGRADE
Terms in this set (137)
Histamine2 blocking agents double alendronate
bioavailability, but the impact is unknown. Aspirin may
Bioavailability of decrease the bioavailability of tiludronate by up to
bisphosphonate drugs 50% when taken 2 hours after the tiludronate.
and appropriate patient Although indomethacin increases the bioavailability of
education tiludronate by 2- to 4-fold, the bioavailability is not
significantly altered by diclofenac; therefore, each
NSAID must be considered individually.
Etidronate has also been associated with fractures in
patients with Paget's disease when they are given high
doses or when therapy lasted longer than 6 months.
These patients must be carefully monitored with x-
Adverse effects rays and laboratory work to assess for these lesions.
associated with long-term The development of a rare form of subtrochanteric
use of bisphonates femur fracture in non-Paget's patients using
bisphosphonates is under close scrutiny and has
contributed to movement away from osteopenia
prevention care to only osteoporosis therapy (FDA,
2010a).
, All doses are taken immediately before or with meals
or snacks with a fatty component. Fruit, hard candy,
fruit juice like drinks, tea or coffee, or popsicles do
not require enzymes (CFF, 2009). Capsules may be
opened and sprinkled on food. Capsules with enteric-
coated beads should not be chewed. They may be
sprinkled on soft acidic food that is not hot and that
can be swallowed without chewing, such as
applesauce or gelatin. Swallow immediately because
the proteolytic enzymes may irritate the mucosa.
Specifics about Following with a glass of water or juice or eating
administration and immediately after taking the drug helps to ensure that
education regarding the medication is swallowed and does not remain in
pancreatic enzymes contact with the mouth and esophagus for long
periods. Pancrelipase is destroyed by acid. Proton
pump inhibitors, sodium bicarbonate, or aluminum-
based antacids may be used with preparations
without enteric coating to neutralize gastric pH.
Calcium- and magnesium-based antacids should not
be used for this purpose because they interfere with
drug action. Enteric-coated beads are designed to
withstand the acid pH of the stomach. Enteric-coated
formulations should not be mixed with alkaline food
or the coating will be destroyed.
, Adverse effects for the drug class include various
pain syndromes, vertigo, insomnia resulting in daytime
sleepiness and confusion, increased risk of blood
clots, and hair loss. A key concern is the loss of bone
mass. Bone loss can be significant when considering
the concurrent osteoporotic risks of postmenopause.
Common adverse effects Closer monitoring is required. All patients should be
with aromatase inhibitors on calcium and vitamin D supplementation. A relative
leukopenia can occur, but the incidence of viral and
bacteria infections is not considered greater than
matched groups (about 10%). Hypertension occurs in
10% of patients. A life-threatening increase in blood
clotting can result in MI, stroke, or pulmonary
embolus. Hot flashes can be intense.
Aromatase inhibitors
Drugs associated risk for Thyroid hormones
bone loss which should Glucocorticoids
be monitored PPIs
SSRIs
Increased thirst
Frequent urination
Extreme hunger
Unexplained weight loss
Presence of ketones in the urine (ketones are a
byproduct of the breakdown of muscle and fat that
Clinical signs and
happens when there's not enough available insulin)
symptoms DM
Fatigue
Irritability
Blurred vision
Slow-healing sores
Frequent infections, such as gums or skin infections
and vaginal infections
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