Routes of Drug Administration Exam Solution Manual Already Passed
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Course
Food and Drug Administration
Institution
Food And Drug Administration
Routes of Drug Administration Exam Solution Manual Already Passed
What are Routes of drug administration: - Answers 1. The organ or sites via which a drug formulation enters the body
2. Major routes:
- Oral
- Respiratory
- Parenteral
- Dermal
- Ocular
- Body cavities
Enteral Route: - Ans...
Routes of Drug Administration Exam Solution Manual Already Passed
What are Routes of drug administration: - Answers 1. The organ or sites via which a drug formulation
enters the body
2. Major routes:
- Oral
- Respiratory
- Parenteral
- Dermal
- Ocular
- Body cavities
Enteral Route: - Answers Drug administration by mouth and tube feeding using nasogastric,
gastrostomy, and jejunostomy tubes
Oral Route: - Answers 1. When you take drugs by mouth and drug is absorbed from the GI tract
2. Orally administered drugs absorbed mainly from small intestine
3. Little absorption occur in stomach because of small area and short residence time. Small intestine has
larger surface area and long residence time
4. Some drugs may be absorbed in the proximal colon of large intestine
Advantages/Disadvantages of Oral Route: - Answers 1. Advantages:
*Convenient and noninvasive
*Good for ambulatory patients
*Self-administration
2. Disadvantages:
*Not suitable for drugs that degrades in GIT such as insulin and heparin
*First-pass metabolism reduces drug absorption
*Interact with GIT and food
*Unpleasant tests
, What are some types of oral dosage forms? - Answers 1. Tablets
*Solid dosage forms prepared by compression and contain medicinal substances
2. Capsules
*Solid dosage forms in which drug substances and appropriate excipients are enclosed in hard or soft
shell
3. Emulsions
*Drugs are present in mixture of water and oil
4. Suspensions
*Solid drug particles dispersed in suitable vehicle
5. Solutions
*Drugs are present in homogenous solution
Buccal and Sublingual Routes: - Answers 1. Sublingual region
*Drug is placed under the tongue
2. Buccal region
*Drug is held between cheek and gingivae adjacent to teeth
Advantages/Disadvantages of Buccal and Sublingual Routes: - Answers 1. Advantages:
*Avoids first-pass metabolism and GIT degradation
*Can be used in unconscious patients
2. Disadvantages:
*Not very pleasant
*Not good for drugs that degrade in saliva
Define First-Pass Metabolism: - Answers 1. Drugs absorbed after oral administration enters the liver
before entering the systemic circulation
2. Drugs that degrades in liver or intestine have poor systemic availability when given orally
Parenteral Routes: - Answers 1. Meaning outside of intestine (para = besides, enteron = intestine)
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