Contemporary Pharmacotherapeutics
C352 – WGU 2024 2025 questions and
answers
Ultimate Guide to Excelling in Contemporary
Pharmacotherapeutics C352 - WGU
1) Which of the following is true regarding calcium channel antagonist overdose?
A. Hypoglycemia occurs due to excess insulin release
B. The drugs in the chemical classes of calcium channel antagonists differ in their predominant toxicity
upon overdose
C. Immediate-release formulations often delay the onset of toxicity of by 6 to 18 hours
D. Concurrent ingestion of β-adrenergic blockers or digitalis may worsen the cardiovascular toxicity
D. Concurrent ingestion of β-adrenergic blockers or digitalis may worsen the cardiovascular toxicity
3) A 65-year-old woman with type 2 diabetes, hypertension, osteoporosis, and atrial fibrillation has a BP
of 150/96 mm Hg (150/90 mm Hg when repeated), heart rate of 68 beats/min, potassium of 3.2 mEq/L,
and a serum creatinine of 2.3 mg/dL. She reports an allergy to hydrochlorothiazide (severe gout).
Presently, she is on diltiazem CD (Cardizem CD) 360 mg daily. Which of the following drugs would be the
most appropriate to add to her regimen?
A. Chlorthalidone (Hygrotin) 12.5 mg daily
B. Amlodipine (Norvasc) 5 mg daily
C. Valsartan (Diovan)160 mg daily
D. Atenolol (Tenormin) 25 mg daily
C. Valsartan (Diovan)160 mg daily
4) Which of these drugs is preferred as an addition to therapy for a patient currently treated with
metoprolol (Lopressor) 200 mg daily who is post-MI (1 month ago) with a BP of 146/88 mm Hg (144/86
mm Hg when repeated)?
,A. Chlorthalidone (Hygrotin)
B. Verapamil (Isoptin)
C. Amlodipine (Norvasc)
D. Lisinopril (Prinvil)
D. Lisinopril (Prinvil)
5) Which of the following is preferred as initial antihypertensive therapy for a 63-year-old woman who is
diagnosed with hypertension and has a history of ischemic stroke (6 months ago), with a BP of 186/108
mm Hg (184/106 mm Hg when repeated)?
A. An ARB alone
B. A thiazide diuretic with a nonselective β-blocker
C. A thiazide diuretic with an ACE inhibitor
D. An ACE inhibitor with an ARB
C. A thiazide diuretic with an ACE inhibitor
A 69-year-old woman with a history of angioedema (from lisinopril), hypertension, and type 2 diabetes is
currently receiving hydrochlorothiazide (HCTZ) 25 mg daily and carvedilol (Coreg) 25 mg twice daily.
Today her blood pressure is 138/82 mm Hg (138/84 mm Hg when repeated) and heart rate is 56
beats/min. Urinalysis shows 400 mg albumin/24 hours, serum creatinine is 1.2 mg/dL, potassium is 3.8
mEq/dL, weight is 90 kg, and height is 65″. She complains of heartburn, a dry cough, constipation, and
fatigue when she exercises. She normally exercises three times per week, and follows a DASH dietary
plan.
6) Which of her complaints is most likely from one of her antihypertensive medications?
A. Heartburn
B. Dry cough
C. Constipation
D. Fatigue
D. Fatigue
,7) Which of the following is the most appropriate modification to her regimen?
A. Decrease carvedilol to 12.5 mg twice daily and add valsartan (Diovan).
B. Decrease carvedilol (Coreg) to 12.5 mg twice daily and add enalapril.
C. Replace carvedilol with valsartan (Diovan) and hydrochlorothiazide with furosemide (Lasix).
D. Replace hydrochlorothiazide with spironolactone (Aldactone) and felodipine (Cabren).
A. Decrease carvedilol to 12.5 mg twice daily and add valsartan (Diovan).
8) A 55-year-old man with hypertension and no other chronic medical problems is currently treated with
hydrochlorothiazide 50 mg daily, irbesartan (Avapro) 300 mg daily, carvedilol (Coreg) 25 mg twice daily,
and amlodipine (Norvasc) (10 mg daily. His BP is 144/96 mm Hg (146/94 mm Hg when repeated). He is
adherent with all of these medications. Serum creatinine is 1.2 mg/dL, potassium is 4.2 mEq/L. Which of
the following is the most appropriate to add to his regimen?
A. Terazosin (Hytrin) 2 mg daily
B. Spironolactone (Aldactone) 25 mg daily
C. Clonidine (Catapress) 0.1 mg twice daily
D. Chlorthalidone (Hygrotin) 12.5 mg daily
B. Spironolactone (Aldactone) 25 mg daily
9) RG is a 68-year-old female who presents to the clinic with c/o chest pain that occurs while she is
gardening and is relieved with rest. She has a PMH of hypertension. Current meds include metoprolol 25
mg twice daily and HCTZ 25 once daily. Current vitals signs are: BP: 128/78, P: 70, and RR: 12. Select the
treatments that would be appropriate for this patient.
A. Increase metoprolol (Lopressor) to 50 mg twice daily
B. Begin aspirin 81 mg once daily
C. Begin amlodipine (Norvasc) 2.5 mg once daily
D. Increase HCTZ to 25 mg twice daily
A. Increase metoprolol (Lopressor) to 50 mg twice daily
B. Begin aspirin 81 mg once daily
, 10) Which of the following is an adverse effect of immediate release nifedipine (Procardia) that limits its
use for chronic stable angina?
A. Tachycardia
B. Bradycardia
C. Hypertension
D. Hypotension
A. Tachycardia
11) Co-therapy is often used in treatment of illnesses. Of the following combinations of antianginal drugs
which is most likely to produce a drug-drug interaction?
A. Verapamil (Calan SR) and ranolazine (Ranexa)
B. Diltiazem (Cardizem) and isosorbide dinitrate (Isordil)
C. Metoprolol (Lopressor) and isosorbide dinitrate (Isordil)
D. Metoprolol (Lopressor) and amlodipine (Norvasc)
A. Verapamil (Calan SR) and ranolazine (Ranexa)
12) Which of the following drugs should be avoided in the treatment of variant (Prinzmetal's angina)?
A. Nifedipine
B. Isosorbide mononitrate
C. Metoprolol
D. Verapamil
C. Metoprolol
13) Which one of the following is the recommended initial drug therapy for angina once the use of
nitroglycerin is no longer adequate?
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