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USMLE Learning checks Exam Questions with complete Answers 2024/2025

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USMLE Learning checks Exam Questions with complete Answers 2024/2025 Shiguella - correct answer Inactivate 60S ribosome by removing adenine from rRNA. enhances cytokine release causing HUS EHEC Shiga-like toxin - correct answer Inactivate 60S ribosome by removing adenine from rRNA. enhanc...

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  • October 8, 2024
  • 20
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • USMLE
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KieranKent55
USMLE Learning checks Exam Questions with
complete Answers 2024/2025

Shiguella - correct answer Inactivate 60S ribosome by
removing adenine from rRNA. enhances cytokine release causing
HUS


EHEC Shiga-like toxin - correct answer Inactivate 60S
ribosome by removing adenine from rRNA. enhances cytokine
release causing HUS


ETEC heat labile - correct answer over activates cAMP >
increase Cl secretion in gut and H2O efflux.


ETEC heat stable - correct answer overactivates cGMP >
decrease reabsorption of NaCl and H2O in gut.


B. anthracis - correct answer Edema factor. increase cAMP.


V. cholera - correct answer over activates cAMP by
permanently activating Gs > increase Cl secretion in gut and
H2O


B. pertusis - correct answer over activates cAMP by disabling
Gi impairing phagocytosis to permit survival of microbe.


C. tetani - correct answer tetanoplasmin. inhibitory (GABA and
Glycine) neurotransmiters from reshaw cells in spinal cord.

,C. Botulinum - correct answer Toxin prevents release of
stimulatory Ach signals at neuromuscular junctions > Flacid
paralysis, floppy baby.


C. perfringens - correct answer alpha toxin. phospholipase
(lecithinase) that degrades tissue cell membrane. degradation of
phospholipids > myonecrosis (gas Gangrene) and hemoptysis
(double zone of hemolysis on blood agar)


S. pyogenes - correct answer Streptolysin O (ASO). protein
that degrades cell membrane. Lyses RBC's contributes to B-
hemolysis; host antibodies against ASO used to dx rheumatic
fever.


S. aureus - correct answer Toxic shock syndrome toxin. Bring
MHC II and TCR in proximity to outside of antigen binding site to
fuse overwhelming release of INF-y and IL-2 leading to shock.


S. pyogenes - correct answer Exotoxin A leading to TSS


Toxic shock syndrome (S.aureus) - correct answer fever, rash,
shock, other toxins cause scalded skin syndrome (exfoliative
toxin) and food poisoning (enterotoxin)


Endotoxin - correct answer an LPS found in outer membrane
of gram (-)
Edema
Nitric oxide

, DIC/Death
Outer membrane
TNF-a
O-antigen
eXtremely heat stable
IL-1
Neutrophil chemotaxis


Phage conversion permitting exotoxin production - correct
answer genes of the 5 following bacterial toxins are encoded in
a lysogenic phage (ABCDE):
shigA-like toxin
Botulinum
Cholera
Diphteria
Erythrogenic toxin of S. pyogenes.


cribiform plate - correct answer CN I


Optic canal - correct answer CNII, ophtalmic artery, central
retinal artery


Superior orbital fissure - correct answer CN III,IV,V1,VI,
ophtalmic vein, sympathetic fibers.


Foramen rotundum - correct answer CN V2

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