PHYSICOCHEMICAL DRUG INTERACTIONS
AND INCOMPATIBILITIES EXAM REVIEW
WITH 220+ QUESTIONS AND CORRECT
ANSWERS RATED A+
A combined effect that is less than either component alone
A. Antagonistic
B. Additive
C. Synergistic
D. Potentiation Correct Answer A. Antagonistic
A combined effect that is the sum of the single components
A. Antagonistic
B. Additive
C. Synergistic
D. Potentiation Correct Answer B. Additive
A combined effect that is greater than the sum of the single
components
A. Antagonistic
B. Additive
C. Synergistic
D. Potentiation Correct Answer C. Synergistic
A type of synergisitc effect; only one of the components exert the
action that is made greater by the presence of the second
A. Antagonistic
B. Additive
C. Synergistic
,D. Potentiation Correct Answer D. Potentiation
Which of the following may be responsible for the absorption of
highly charged drugs such as the quaternary ammonium salts and
sulfonic acid derivatives?
A. Electrostatic attraction
B. Salting out
C. Salting in
D. Cation-anion interactions Correct Answer D. Cation-anion
interactions
Ion pairs may be defined as neutral species formed by ____
between oppositely charged ions in solutions
A. Electrostatic attraction
B. Salting out
C. Salting in
D. Cation-anion interactions Correct Answer A. electrostatic
attraction
Ion pairs are often sufficiently ____ to dissolve in nonaqueous
solvents
A. hydrophilic
B. hydrophobic
C. lipophilic
D. lipophobic Correct Answer C. lipophilic
Salts that decrease the solubility of a solute in a given solvent are
said to ____ the solute
A. Salt out
B. Salt in Correct Answer A. Salt out
,Salts that increase the solubility of a solute in a given solvent are
said to _____ the solute
A. Salt out
B. Salt in Correct Answer B. Salt in
_____ the ionic strength of a solution may increase the solubility
of a solute
A. increasing
B. decreasing Correct Answer A. increasing
Relates to the interaction between a metal ion and another
species known as the ligand
A. Ion exchange interactions
B. Cation-anion interaction
C. Chelation
D. electrostatic attraction Correct Answer C. Chelation
Which one is the electron pair donor?
A. the metal
B. the ligand Correct Answer B. the ligand
Which one is the electron pair acceptor?
A. the metal
B. the ligand Correct Answer A. the metal
Many chelating agents act in the form of ____ that coordinate to a
metal ion
A. anion
B. cation Correct Answer A. anion
, Chelation can lead to ____ absorption
A. increased
B. decreased
C. A & B
D. no change in Correct Answer C. A & B
Tetracycline chelation with metal ions ____ drug absorption
A. increases
B. decreases Correct Answer B. decreases
Tetracyclines form _____ complex molecules by metal ion
chelation with various antacids
A. soluble
B. insoluble Correct Answer B. insoluble
_____ is an insoluble quaternary ammonium anion-exchange
resin that, when administered orally, binds bile salts and
increases their elminination.
A. Warfarin
B. Colestyramine
C. Promethazine
D. Globulins Correct Answer B. Colestyramine
What is Colestyramine used as?
A. Hypocholesteraemic agent
B. Hypercholesteremic agent Correct Answer A.
HYPOcholesteraemic agent
What can Colestyramine bind to?
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller wachiraMaureen. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $25.48. You're not tied to anything after your purchase.
