Exam (elaborations)
PCB 3233 - Immunology Exam 3 correctly answered to pass
- Course
- PCB 3233
- Institution
- University Of Central Florida
PCB 3233 - Immunology Exam 3 correctly answered to pass
[Show more]
Content preview
PCB 3233 - Immunology Exam 3Helper T cells associate with which class of MHC molecules? - correct answer ✔✔MHC Class 2
(extracellular infection)
Interferon function - correct answer ✔✔Viral fighting, they activate NK cells which then tell our infected
cells to die by apoptosis.
What process creates the variable region domain for both TCRs and BCRs? - correct answer ✔✔Somatic
Recombination
What the different types IFN-1? - correct answer ✔✔Alpha and Beta
What are the differences and similarities between CD8 T Cells and NK cells? - correct answer ✔✔The
both have the same cytotoxic granules, NK cells are activated faster, because they come out of the bone
marrow "ready to go". CD8 T cells recognizes MHC Class 1 + peptide (antigen) on a pathogen, while NK
cells recognize normal MHC Class 1 molecules on the surface of our cells and activating ligands that
infected cells put up on their surface.
2 types of activating ligands - correct answer ✔✔MIC - A and MIC - B, they bind to activating receptors
on activating NK cells
Type 2 interferon - correct answer ✔✔Also know as IFN- gamma, activates macrophages
IL - 12 - correct answer ✔✔Inflammatory cytokine that activates NK cells which then produces IFN -
gamma which then activate macrophages.
Which complement receptors can recognize C3b? - correct answer ✔✔CR 1 - CR 4
Which Professional Antigen Presenting Cell (Professional - APC) is strong enough to activate a CD8 T cell
from a naive state? - correct answer ✔✔Dendritic cells
, C3 convertase of the Alternative Pathway - correct answer ✔✔C3bBb
When will NK cells make interferon gamma? - correct answer ✔✔When they are activated by IL-12
(inflammatory cytokine)
Explain the activation of macrophage feedback loop - correct answer ✔✔NK cells become activated by
IL- 12, they produce interferon gamma, IFN- gamma activates macrophages, macrophages secrete IL-12
(+ other cytokines)
Describe the chains in a TCR? - correct answer ✔✔V region followed by a C region followed by a
membrane anchoring domain
Where is the most variable region of the TCR? - correct answer ✔✔V-alpha and V- beta
CDR - correct answer ✔✔area of hypervariability condensed in loops in domain farthest from the T cell
membrane
How many CDRs does each TCR chain have? - correct answer ✔✔3, CDR 1 - 3
How many binding sites do TCRs have? - correct answer ✔✔1 binding site for antigen
What is the fundamental difference between T cells and B cells? - correct answer ✔✔T cells do not
undergo any further changes after antigen stimulation whereas B cells continue to diversift
Function of B cells - correct answer ✔✔mediating effector functions
Function of T cells - correct answer ✔✔to recognize antigen
What part in T cells handles the mediating effector functions? - correct answer ✔✔the proteins
produced by the T cells
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Sakayobako30. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $12.99. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
52510 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now