UNE Biochemistry Exam 2024 | UNE
Biochemistry Exam Update 2024 Questions
and Correct Answers Rated A+
The glucose-alanine cycle is a method of transferring ammonia from
the skeletal muscle to the liver. In this process the non-toxic carrier of
ammonia is which of the following compounds? -ANSWER-Alanine
Which of the following enzymes is correctly paired with its activator? -
ANSWER-N-acetylglutamate synthatase; arginine
The urea cycle takes place in which of the following subcellular
locations? -ANSWER-the cytosol and the mitochondria
Which of the following enzymes is regulated by N-acetylglutamate
(NAGs)? -ANSWER-CPS I
Which of the following enzymes is the regulatory step in the urea
cycle? -ANSWER-Carbamoyl phosphate synthetase I (CPS I)
Which of the following statements is consistent with nitrogen transport
in the fasted state? -ANSWER-The urea cycle will be active
A comatose infant is brought to the ER. In the course of the
examination, plasma ammonia was found to be elevated 20-fold over
normal values. Urine orotic acid and uracil were both greater than
normal. A defect of which of the following enzymes is the most likely
diagnosis? -ANSWER-Ornithine transcarbamoylase
Your patient presents with a deficiency of the enzyme that catalyzes
synthesis of N-acetylglutamate (NAGs). Which of the following would
,be a consequence of this deficiency in the patient? -ANSWER-
Increased amino acids in the blood
The cellular uptake of LDL increases intracellular cholesterol levels.
This has which of the following impacts on de novo cholesterol
synthesis? -ANSWER-Increases degradation of HMG-CoA reductase
Dietary cholesterol is primarily transported in the body by which of the
following lipoproteins? -ANSWER-Chylomicron
Secondary bile salts are generated by bacterial modification of primary
bile salts in the intestinal lumen. These modifications have which of
the following impacts on bile salt solubility? -ANSWER-Decrease
solubility
A 47-year-old male is prescribed a statin (HMG-CoA reductase
inhibitor) to manage his elevated LDL cholesterol. What is the initial
mechanism of action for obtaining the desired effect in this man? -
ANSWER-Decreasing hepatic cholesterol biosynthesis
A deficiency in the LDL receptor will result in an initial decrease in
which of the following? -ANSWER-Intracellular cholesterol
A 45-year-old man has a mild heart attack and a history of vascular
disease. He is placed on a Mediterranean diet and statin drug therapy.
Which of the following will be the most likely result of this drug
therapy? -ANSWER-Low blood LDLs
A 45-year-old man is found to have an elevated serum triglycerides of
> 730mg/dL. He tells you he forgot to fast before his visit and he ate a
full breakfast of bacon and eggs before the labs were drawn. Which of
the following lipoproteins would be the largest contributors to a
,measurement of plasma triglycerides in this situation? -ANSWER-
Chylomicrons and VLDLs
In the reaction catalyzed by cholesterol ester transfer protein (CETP),
the VLDL particle receives which of the following compounds from
HDL particles? -ANSWER-Cholesterol-ester
In reverse cholesterol transport HDL interacts with the ABCA1
transporter to move cholesterol from the cell to the HDL. This also
requires the activity of which of the following enzyme? -ANSWER-
Lecithin cholesterol acyltransferase (LCAT)
HDL particles interact with VLDL particles to exchange cholesterol
ester for triacylglyerols. Which of the following enzymes is responsible
for this process? -ANSWER-Cholesterol ester transfer protein (CETP)
Which of the following is a major source of extracellular cholesterol for
human tissues? -ANSWER-LDLs
An individual is suspected of having a deficiency in branched chain
keto acid dehydrogenase. Supplementation of which of the following
vitamins or cofactors may help resolve this issue? -ANSWER-
Thiamine
A 55-year old man presents to his primary care physician with bouts of
dizziness and confusion. He is diagnosed with hyperhomocysteinemia
due to a deficiency of cystathionine-ß synthase. In this individual
which of the following amino acids could potentially become essential?
-ANSWER-Cysteine
, Phenylketonuria can be caused by an enzymatic deficiency or it can
present due to a deficiency in which of the following required
metabolic cofactors? -ANSWER-Tetrahydrobiopterin (BH4)
A 17-year old female presents to her primary care and is diagnosed
with a Vitamin B12 (cobalamin) deficiency. In this individual, which of
the following reactions would be compromised? -ANSWER-
Conversion of methyl malonyl-Co A to succinyl-CoA
A 15-year-old female presents to her pediatrician with concerns over
her inability to sleep, increased feelings of depression and generalized
fatigue. A full laboratory work-up is ordered and based on these
findings she is diagnosed with a melatonin deficiency. Based on this
information, metabolism of which of the following amino acids is likely
impaired? -ANSWER-Tryptophan
A 52-year- old male sought medical help complaining about
progressive appearance of hyperchromic (hyper pigmented) papules
on the edge of the second finger of both hands. He also complained
about darkening of urine. Incisional biopsy of one of the spots on his
hands and urine sample tested positive for or homogentisic acid.
Based on these findings a diagnosis of alkaptonuria is made. This
diagnosis is consistent with a deficiency in which of the following
enzymes? -ANSWER-Homogentisate oxidase
Methotrexate is a potent anticancer agent that starves dividing cells of
deoxyribonucleotides through direct inhibition of which of the following
processes? -ANSWER-Metabolism of folic acid
A 47-year-old man complains of pain in the joints of his left big toe,
which are obviously swollen and tender. The pain has been chronic
but became intolerable the day after Thanksgiving when he had a
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