MCB*2050 Final Exam Key Terms with Complete Solutions
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Course
MCB 2050
Institution
MCB 2050
MCB*2050 Final Exam Key Terms with
Complete Solutions
Nucleus - Control center of the cell. Contains DNA. Largest
organelle. Responsible for 1) compartmentalizations of the cellular genome
and its activities and 2) coordination of cellular activities
Nucleoplasm - Fluid-filled interior of the ...
Serves as a barrier to the passage of ions, solutes, and macromolecules
between the nucleoplasm and cytoplasm
Nuclear envelope lumen - ✔✔Separates the inner and outer membrane.
10-50 nm diameter. Continuous with the ER lumen.
Nuclear lamina - ✔✔Located on the inner surface of the nuclear inner
membrane. Network ('mesh') of long, filament-like proteins. Provides
mechanical support to nuclear envelope (binds to nuclear inner membrane
integral proteins). Serves as a scaffold for attachment of chromatin and
nuclear matrix to the nuclear envelope.
ABC nuclear lamins - ✔✔Evolutionary related to proteins that form
intermediate filaments in the cytoskeleton network.
Nuclear pore complex (NPC) - ✔✔Channels/doorways in the nuclear
envelope. Responsible for the regulated trafficking of all
substances between the nucleus and cytoplasm. Allows trafficking of small,
polar molecules, RNAs, and proteins. Typically 3000-4000 per nucleus (the
number is related to nuclear activity). Large highly complex structure (~30X
> ribosome). Structure is an 8-fold symmetrical structure organized around
a large, central aqueous channel. Size exclusion limit - molecules >40 kDa
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