PC707 Module 3-GI Questions And Complete
Answers
Sodium-based antacids should be avoided in patients with cardiovascular disease
Magnesium-containing antacids may cause diarrhea, contraindicated in renal insufficiency, may
decrease absorption of warfarin (Coumadin)
Bismuth subsalicylate cont...
H2RA MOA Blocks H2 receptors to reduce the volume of gastric acid (onset of action
slower than antacids but faster than PPIs - moderate acid reduction)
H2RA Safety Concerns Cimetidine is a potent CYP inhibitor, many D2D interactions
(warfarin, theophylline, phenytoin, opioids)
,PC707 Module 3-GI Questions And Complete
Answers
Potential pneumonia
Ranitidine (original Zantac) pulled off market d/t carcinogens, new formulation is famotidine
PPI Examples Omeprazole (Prilosec), esomeprazole (Nexium), lansoprazole (Prevacid),
pantoprazole (Protonix)
PPI Indications Gastric and duodenal ulcers
Most effective at suppressing acid but the slowest onset of action compared to antacids and
H2RAs
PPI MOA Prodrug inhibition of the proton pumps that secrete gastric acid
PPI Safety Concerns Fractures
Pneumonia
Acid rebound
, PC707 Module 3-GI Questions And Complete
Answers
C. diff
Can reduce the absorption of drugs that rely on acid
Prostaglandin Analog Example Misoprostol (Cytotec)
Prostaglandin Analog Indication Prevention of GI ulcers related to long-term NSAID use
Prostaglandin Analog MOA Protects gastric mucosa by binding to prostaglandin
receptors. This inhibits gastric acid secretion and increases mucus production
Prostaglandin Analog Safety Concerns Causes uterine contractions, therefore Category X
(contraindicated) in pregnancy
**Off-label use for induction of labor**
Mucosal Protectant Example Sucralfate (Carafate)
Mucosal Protectant Indication Antiulcer
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