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CRNA Interview Exam Questions and Answers (Latest Update 2025)
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CRNA Interview Exam Questions and Answers (Latest Update 2025)
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CRNA Interview Exam Questions andAnswers (Latest Update 2025)
Norepinephrine Mechanism of Action (MOA) - Correct
Answer ✅ A1, A2, B1 agonist.
Primary agent used in distributive shock because it's ability
to recruit venous volume and augment preload, while
increasing arterial tone, and increasing cardiac output.
Alpha one causing peripheral smooth muscle contraction.
(low dose venous, high dose venous and arterial).
Alpha 2 adrenoreceptor agonism actually antagonizes the
release of norepinephrine in the CNS, but these receptors are
less present in peripheral vasculature and thus, their anti-
hypertensive effects are overtaken by A1 agonism.
These alpha effects can increase SVR and thereby increase
cardiac workload, decrease cardiac output, and increase
coronary perfusion pressure.
The slight B1 agonism increases inotropy and chonotropy
sufficiently to overcome these A1 effects and result in a fairly
,CRNA Interview Exam Questions and
Answers (Latest Update 2025)
"pure" vasopressor. Increasing contraction of the heart and
increasing AV nodal conduction.
**First line agent in septic shock
Epinephrine MOA - Correct Answer ✅ A1
A2
B1 - Stimulate Heart Rate through SA node, increase
conduction through AV node. Increase contractility to ATRIAL
and VENTRICULAR cardiac muscle.
B2 - Smooth muscle relaxation. Resulting in dilation of the
bronchial tree, coronary arterial dilation. Also plays a role in
insulin and glucagon secretion in the pancreas. Also increases
cardiac inotropy/chonotropy
B3 - Increase lypolysis and thermogenesis in brown adipose
tissue.
,CRNA Interview Exam Questions and
Answers (Latest Update 2025)
**Cardiogenic shock or other shock states with a cardiac
component.
Adjunctive therapy in severe septic shock
IVP in cardiac arrest to augment CPP
IVP while introducing PPV/intubation
Precedex MOA - Correct Answer ✅ Dexmetatomadine is an
alpha 2 adrenoreceptor agonist that acts both on the
presynaptic neuron and postsynaptic neuron. Inihibiting
norepinephrine release pre-synaptically reduces/halts the
transmission of pain, while postsynaptically acts to reduce
sympathetic tone. The combination of these effects is
anesthesia with analgesia and anxiolysis.
loading dose is 1 mg/kg while gtt is .2-1.5 mg/kg/hr
**This agent is often used for patients who would not tolerate
a precipitous drop in their sympathetic tone, for those
patients in severe alcohol withdrawal.
, CRNA Interview Exam Questions and
Answers (Latest Update 2025)
propofol MOA - Correct Answer ✅ Propofol is a lypophylic
general anesthetic unlike any drugs of the class
benodiazapen, barbituate, or A2 agonist. Its mechanism is
proposed to be a GABA (inhibitory neurotransmitter) agonist
causing global CNS depression
Dosing for procedural sedation of .1-.5 mg/kg as a loading
dose with repeat doses. gtt titration ranging from 10-60
mcg/kg/min
**Anesthetic
Sedation for mechanically ventilated ICU patients
Procedural sedation
Phenylephrine MOA - Correct Answer ✅ Pure Alpha
adrenergic receptor agonist. Causing increase in SVR through
systemic arterial vasoconstriction. This also causes a dose
dependent increase in systolic and diastolic blood pressure
and thereby decreasing cardiac output, especially in patients
with heart failure.
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