CTBT Prep Course Module Two: Donor Screening
Additional Non-required blood test - ANS--must be included in the donor's record and must be
considered during eligibility determination
-ex: CMV, EBV, blood types ect.
Adequate Information - ANS-Information sufficient for the donor, the authorizing person, or the
living donor to make a voluntary decision regarding the gift of tissues for transplantation,
therapy, research, and/or education.
Antibodies (Ab) - ANS--Created by immune system. After contact with RCDADs
-Also known as 'Anti', 'IgG, or IgM'
-Takes time to develop
-Immunoglobulin - protein molecule in the immune system
-IgG has a binding site for an antigen
-IgM binds 5 IgG molecules and creates 'clump' (agglutination) of molecules.
-Antibody levels can change over time.
Antigen (Ag) - ANS--part of the RCDAD
-Antigens are from the surface of cells or virus (e.g. Viruses, Bacteria, Fungi, Your own body
cells)
-They cause the immune system to create antibodies
-They are unique to each virus/cell.
-can be on the surface or in the 'core'
Authorization - ANS-Permission is given after Adequate Information concerning the donation,
recovery, and use of the tissue is conveyed.
Blood - ANS--Counted for hemodilution for 48 hours
-whole blood
-packed red blood cells
-Leukocyte reduced red blood cells
Blood Composition - ANS--a connective tissue (cells in a matrix that perform a specific function)
in homeostasis
-Parts are: 55% Plasma, Buffy Coat <1%, and erythrocytes 45%
Colliods - ANS--derived from blood and pharmaceuticals (synthetic)
-Counted for hemodilution for 48 hours
Core Elements for Authorization - ANS--Donors Name
-Authorizing persons: Name, mailing address, phone number
, -explanation that the tissue is a gift
-a description of the general types of tissue recovered
-a discription of the permitted uses of the tissue
-explanation that the following actions will be taken
-access and disclotion of medical records
-testing and repording for rcdads
-removal of samples for testing perposes
-release of ME records
-notice that transport, archiving of samples, and pictures may occur
-contact info for the organization
-any additional info required by law
Core Elements for Informed Consent - ANS--Living Donors name
-identity of the person authorized by law to consent on behalf including; relationship, name,
address, and phone number
-explanation that the tissue is a gift
-general description of the types of tissues given
-a description of the permitted uses of the tissue
-release of relevant medical records
-permission for disease testing and notification that positive results will be reported
-contact info for the organization
-info about possible risks and benefits
-additional info according to law.
-other info: tissue may be used internationally
Crystalloids - ANS--NS
-Dextrose D5
-ringers
-bicarb
-Counted for hemodilution for 1 hour
Diagnostic Test - ANS--establishes presence or absence of disease
Document of Authorization - ANS--Legal record that is signed by the authorizing person (not the
donor) AFTER death
-defines and allows postmortem recovery
-discusses transplant, therapy, research, and/or education
Document of Gift - ANS--Legal record of the donor's wishes
-defines and allows postmortem recovery
-discusses transplant, therapy, research, and/or education
-signed by the donor (or the legal authority) DURING the donors lifetime
Donation Coordinator - ANS--a responsible person who seeks authorization or informed consent
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