Exam (elaborations)
OST 575 - Exam 3 Liver Function Tests
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OST 575 - Exam 3 Liver Function Tests...
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OST 575 - Exam 3 Liver Function TestsWhat are the players that can be tested to assess liver function? - ANSWER
aminotransferases
serum proteins (ALBUMIN)
Bilirubins
Blood clotting factors
alkaline phosphatase and gamma-glutamyl transpeptidase
What is the function of an aminotransferase enzyme in the liver? - ANSWER catalyzes
the transfer of NH2 group from a *donor alpha amino acid* to an *acceptor KETO ACID*
What is the reason for having aminotransferase enzymes in the liver? - ANSWER can
make a particular amino acid needed by a cell
can get rid of a particular amino acid by transferring the NH2 to alpha-ketoglutarate
(*done for urea extretion*)
Are the aminotransferase enzymes in the liver EXTRAcellular or INTRAcellular? -
ANSWER INTRACELLULAR
Why is it important to know that aminotransferase enzymes in the liver are found
intracellular and NOT in the plasma? - ANSWER Elevated plasma levels of
aminotransferases usually indicate *damage to tissues* rich in these enzymes
What are the two specific aminotransferase liver enzymes usually measured? - ANSWER
AST
ALT
Which liver aminotransferase, AST or ALT, is more specific for liver disease? Which is
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