FLG 332 Summaries for Study Unit 4 (Semester Test 2 & exam). Haematology, Red blood cells, Anaemia, Immunology (Third Year).
Most important notes for the study unit.
HbS
« Valine is substituted for glutamic acid at position 6 of β-chain in HbA
« When deoxygenated, polymerises to form long fibres
« Fibres aggregate and distort RBC causing “sickling” of the cell
Sickle cells
• Decrease half-life of RBC ⇒ more prone to damage
• Results in haemolytic anaemia
MICAELA DE JAGER 2
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