OST 575 - Exam #3 Questions And Correct
Answers --> Understanding LFTs
What are the enzyme tests for liver damage? - answerTransaminase (AST, ALT)
Alkaline phosphatase
gamma glutamyl transpeptidase (GGT)
What lab levels are tested to determine how well the liver is functioning? - answerAlbu...
What are the enzyme tests for liver damage? - answer✔Transaminase (AST, ALT)
Alkaline phosphatase
gamma glutamyl transpeptidase (GGT)
What lab levels are tested to determine how well the liver is functioning? - answer✔Albumin
Prothrombin time
What can also be tested to detect if there is liver damage that is NOT an enzyme and can be
detected based on physical presentation? - answer✔bilirubin
What are some general symptoms of liver disease? - answer✔JAUNDICE
arthralgias
myalgias
*rash*
anorexia
weight loss
muscle wasting
*pruritis*
What are the stigmata of liver disease? - answer✔Spider angioma
ascites
palmar erythema
jaundice/ sclera icterus
gynecomastia
What are some common meds that can cause an *increase in LFTs*? - answer✔NSAIDs
Antibiotics
*Statins*
antiepileptics
anti TB meds
*herbal remedies*
The transaminase enzymes (AST, ALT) are sensitive indicators for what? -
answer✔hepatocellular damage or interference with bile flow
What transaminase enzyme, AST or ALT, is more specific for the liver? - answer✔ALT
What is a downfall of using AST and ALT values to assess liver disease? - answer✔Does NOT
measure liver function
If BOTH AST and ALT are increased >1000 (high), what are some possible causes? -
answer✔*Hepatitis (acute, viral)*
*Autoimmune hepatitis*
Hep B
Drugs (acetaminophen)
shock liver (ischemic liver from decreased blood flow)
What are the values of AST and ALT that indicate alcoholic hepatitis? - answer✔AST > ALT
(2:1 ratio)
*overall though, not more than 300*
A low level of ALT in the serum can be due to what? - answer✔alcohol induced deficiency of
pyridoxal phosphate
What is unusual about the AST and ALT levels of someone with end stage cirrhosis? -
answer✔can have NORMAL AST and ALT levels because the hepatocytes are dead
What tests must be done if the AST and ALT levels are inconclusive and do not give accurate
results? - answer✔test for PT (INR) or albumin
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