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ASCP CGMBS Exam Study Questions and Answers 2024/2025 $11.49   Add to cart

Exam (elaborations)

ASCP CGMBS Exam Study Questions and Answers 2024/2025

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BCR;ABL1 fusion protein → t(9;22)(q34;q11) Acute Promyelocytic Leukemia (APL) → t(15;17) a fusion of PML and RARA Burkitt's Lymphoma → t(8;14) the breakpoints on chr.8 are spread of 190 kbp region 5' to and within the CMY C gene Follicular Cell Lymphoma (FCL) → t(14;18) translocatio...

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  • October 15, 2024
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  • 2024/2025
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  • ASCP CGMBS
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ASCP CGMBS Exam Study Questions and
Answers 2024/2025
BCR;ABL1 fusion protein

→ t(9;22)(q34;q11)


Acute Promyelocytic Leukemia (APL)

→ t(15;17) a fusion of PML and RARA


Burkitt's Lymphoma

→ t(8;14) the breakpoints on chr.8 are spread of 190 kbp region 5' to and within the C-
MY C gene


Follicular Cell Lymphoma (FCL)

→ t(14;18) translocation disregulate BCL2, which inhibits apoptosis in B lymphocytes,
which leads to survival of genetically damaged cells


Mantle Cell (MCL)

→ t(11;14) translocation increases expression of CCND1


Chronic Myelogenous Leukemia (CML)

→ t(9;22) aka Philadelphia Chromosome, translocation occurs within two genes: the
breakpoint cluster region (BCR) on chr.22 and the cellular counter part of the Abelson
Leukemia virus tyrosine kinase (c-abl) on chr.9


Marginal Zone Lymphoma


→ t(11;18)



1|Page| GradeA+ | 2 0 0 2 5

, 2 0 2 4 /2025 | © copyright | This work may not be copied for profit gain Excel!

Vorinostat/Zolina

→ second-line drug for cutaneous T-cell lymphoma. Treatments are often used in
combination with phototherapy and chemotherapy


Irinotecan

→ UGT1A1 - Prevents DNA from unwinding by inhibition of topoisomerase 1


Warfarin (Coumadin)


→ CYP2C9 and VKORC1 - Vitamin K antagonist; metabolized primarily via oxidation in
the liver by CYP2C9 and exerts its anticoagulant effect by inhibiting the protein
vitamin epoxide reductase complex, subunit 1 (VKORC1)


Tamoxifen

→ CYP2D6 - anti estrogen therapy for hormone receptor-positive breast cancer in pre-
menopausal women


Azathioprine


→ TPMT - immunosuppresive used in organ transplant


Carbamazepine

→ Ineffective to HLA B1502


Plavix

→ CYP2C19 - anticoagulant (stroke, heart attack)


Herceptin

→ HER2/Neu - anti Her2/neu


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