topoisomerase 1
→ Making single-stranded DNA breaks to relieve supercoiling at origin
topoisomerase 2
→ An enzyme that breaks both strands (a DNA double helix), rotates the ends, and seals
the break.
→ *USES ATP*
DNA gyrase
→ type of topoisomerase 2
DNA helicase
→ An enzyme that...
→ prokaryotic: In charge of synthesizing nucleotides onto the leading end in the classic 5'
to 3' direction.
Dna polymerase epsilon
→ *leading* strand synthesis; requires presence of helicase
→ nucleotide and base excision repair
DNA polymerase delta
→ eukaryote: completes replication on the *lagging* strand; binds more tightly to DNA
sliding clamp
→ nucleotide and base excision repair
DNA sliding clamp
→ keep DNA polymerase firmly attached to the template while it is synthesizing new
strands of DNA
DNA ligase
→ an enzyme that eventually joins the sugar-phosphate backbones of the Okazaki
fragments
template strand or non-coding strand
1|Page| GradeA+ | 2 0 0 2 5
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