CBN Exam 2 Questions With Correct
Answers
What methodology might you use if you wanted cell-type specificity as well as quantitative
analysis? - answerTRAP (translating ribosome affinity purification)
What are the 4 symptoms of major depressive disorder that were highlighted in class? Or just a...
What behavior exhibited during the forced swim test is said to be indicative of despair? -
answer✔Immobility
In the forced swim test, how do antidepressants impact time spent immobile? - answer✔Trick
question! They all seem to work differently.
E.g.
- Desipramine "worked" in 75% of strains
- Fluoxetine "worked" in 25% of strains
If mice in an experimental design show no preference for sucrose water over regular water, what
might this tell you? - answer✔The mice are exhibiting signs of anhedonia indicated by their loss
of interest in an otherwise universally pleasurable stimulus.
How does an effort-related decision making task indicate whether a mouse may be exhibiting
signs of anhedonia? - answer✔Whether it chooses the high reward + high work option
Describe the 5-HT deficiency hypothesis. - answer✔Too little serotonin causes depression
Describe the neurogenesis hypothesis of depression. - answer✔Depression is caused by impaired
neurogenesis
Describe the neuroendocrine hypothesis. - answer✔Depression is caused by excessive activation
of the hypothalamus-pituitary-adrenal (HPA) axis.
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