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SPMM Paper A Pharmacology: Questions & Answers (Complete And Verified)
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SPMM Paper A Pharmacology: Questions & Answers (Complete And Verified)
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SPMM Paper A Pharmacology: Questions & Answers(Complete And Verified)
Lithium cardiac adverse effects Right Ans - Sick sinus syndrome
Aggravation of Brugada syndrome
T wave flattening / inversion - common
Sodium valproate effects on blood cells Right Ans - Thrombocytopenia
Red cell hypoplasia
Leucopenia
slow acetylator phenotype Right Ans - Polymorphism of the N-
acetyltransferase 1&2 enzymes
Low levels lead to slow metabolism of certain medications
60% of caucasians and 15% of Asians have the 'slow' phenotype
Acetylator dependent drugs (and effects if slow phenotype) Right Ans -
Nitrazepam - drowsiness
Isoniziad - peripheral neuropathy
Hydralazine/procainemide - drug induced lupus
Topiramate side effects Right Ans - Sedation, mental dulling, kidney stones,
weight loss
Tranylcypromine Right Ans - MAOI with amphetamine-like structure
Potentially addictive
Trazodone QTc effect Right Ans - Prolongation at normal doses
Risk factors for clozapine induced neutropenia Right Ans - Early after
initiation
Young age
Afro-Caribbean
Low baseline white-cell count
Gabapentin MOA Right Ans - Binds to voltage gated calcium channels
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