Rhabdomylosis, a rare skeletal muscle breakdown that
may cause renal dysfunction, may occur as an adverse
reaction to: Correct Answer atorvastatin
Normal changes with aging include decreases in all for the
following except: Correct Answer There is an increase in
cerumen production with aging. There is a decrease in
number of taste buds, sweat gland activity, and tear
production.
An advantage of the transdermal patch over oral delivery
of estrogen for the woman experiencing menopausal
symptoms is that the transdermal delivery method: Correct
Answer B) has less adverse effects on coagulation factors.
Estrogen delivered via a transdermal patch has no effect
on cardiovascular markers (HDL-C, LDL-C, triglycerides,
C-reactive protein). There is less effect on coagulation
factors and a lower risk of venous thromboembolism with
transdermal estrogen compared with oral estrogen in the
menopausal woman.
Which of the following statements in regard to
pharmacokinetic changes during pregnancy is correct?
,Correct Answer B) Drug elimination may be faster
because of an increase in glomerular filtration rate.
Glomerular filtration rate (GFR) begins increasing early in
pregnancy, peaks at 9 to 16 weeks, and plateaus at a rate
about 50% above that of prepregnancy at 34 to 36 weeks.
Increased GFR can result in faster elimination of some
drugs, resulting in a lower serum concentration during
pregnancy.
The woman who is going to take ospemifine for treatment
of dyspareunia related to vulvovaginal atrophy should be
advised that she: Correct Answer C) may experience hot
flashes as a side effect of this medication.
Ospemifine is a SERM taken as a daily oral dose to treat
moderate to severe dyspareunia related to vulvovaginal
atrophy. Hot flashes are a common side effect. Estrogen
should not be used in combination with ospemifine. No
studies have looked at using a progestogen with
ospemifine.
A major ovarian peptide that contributes to FSH regulation
is: Correct Answer Inhibin B
The partial estrogen agonist effect of tamoxifen may result
in: Correct Answer increased risk of endometrial cancer
An advantage of continuous-combined HT over
continuous-cyclic HT regimens is: Correct Answer C)
lower cumulative dose of progestin.
,Estrogen and progestogen are taken every day with a
continuous-combined HT regimen with lower cumulative
dose of progestogen than a continuous-cyclic HT regimen
in which estrogen is taken every day and larger doses of
progestogen are added 10 to 14 days each month.
Fluconazole is effective in a one-time dose because it:
Correct Answer D) has a mean elimination half-life of 30
hours.
The predominant estrogen after menopause is: Correct
Answer estrone
The low serum bioavailability of atorvastatin is attributed
to: Correct Answer A) extensive hepatic first-pass
metabolism.
When comparing conjugated estrogen combined with
bazedoxifene (CE/BZA) to conjugated estrogen combined
with medroxyprogesterone acetate (CE/MPA), data have
shown: Correct Answer C) less unscheduled bleeding with
CE/BZA.
Instructions for a patient for whom you are prescribing an
oral bisphosphonate should include: Correct Answer C)
take with eight ounces of plain water.
instructions for ECP Correct Answer ECP is levonorgestril
pill ir ulipristal acetate (UPA) pill (Ella) - delays ovulation
, and transport of sperm and egg, does not disrupt
established pregnancy
take within 120 hours
COCs can be used (ethinyol estradiol _ norgestrel or
levonorgestrel pills) - take in 2 doses 12hrs apart (may
need nausea meds)
resume method of birth control the day after
pregnancy test if no withdrawal bleed within 3 weeks
contraindications for -male condoms - female condoms
Correct Answer male: latex allergy (can use polyurethane)
female: nitrile allergy
instructions on diaphragm Correct Answer insert prior to
intercourse or up to 6hrs prior. 1tbsp of spermicode inside
dome
be sure dome covers cervix
leave for at least 6 hrs after sex
if repeat rounds of sex, insert another spermicide
applicator in vagina but leave diaphragm in place
never leave in >24 hrs
wash with plane soap and water, store in cool dark place
Femcap Correct Answer can be left in for 48hrs after sex
not a great first year failure rate (10% with perfect use,
20% failure rate if theyve had a baby before)
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