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OST 575 Exam-Liver Functions |Questions with 100% Correct Answers
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OST 575 Exam-Liver Functions |Questions with100% Correct Answers
What locations does RBC degradation typically take place? - ✔️✔️liver
spleen
bone marrow
What happens when heme gets separated from global polypeptides during RBC
degradation? - ✔️✔️heme undergoes *oxidation-reduction reactions* to yield
BILIRUBIN and Fe
What are the characteristics of UNconjugated bilirubin? - ✔️✔️hydrophobic
limited solubility in aqueous solutions
*free bilirubin transported to liver for conjugation via albumin*
What is attached to bilirubin to make it conjugated bilirubin? - ✔️✔️glucuronic acid
*makes it much more water soluble, facilitating transport and excretion*
Where does bilirubin become conjugated? - ✔️✔️LIVER
When the assay test for bilirubin is carried out in *citrate buffer (ph = 3)* what
gets measured (conjugated or unconjugated bilirubin)? - ✔️✔️ONLY CONJUGATED
bilirubin (DIRECT BILIRUBIN)
*unconjugated is still attached to albumin so unable to react*
, When the assay test for bilirubin is carried out in *citrate buffer (pH = 3), WITH
DETERGENT*, what gets measured (conjugated unconjugated bilirubin)? -
✔️✔️BOTH are measured (total bilirubin)
*indirect bilirubin (just unconjugated) = total - direct*
Jaundice is due to what? - ✔️✔️hyperbilirubinemia (increased levels of bilirubin in
blood)
What are the 4 phases of hemostasis? - ✔️✔️compression and vasoconstriction
formation of platelet plug
formation of fibrin clot
dissolution of clot
Formation of a fibrin clot consists of what? - ✔️✔️cascade of sequential activation
of coagulation factors
Where are most of the protein factors involved in the fibrin clot cascade
synthesized? - ✔️✔️liver that circulate in plasma as *INACTIVE FORM*
What does the liver express that catalyzes the *vitamin K-dependent
modifications of certain glutamate residues* on factors II, VII, IX, and X? -
✔️✔️gamma-glutamyl carboxylase enzyme
Thrombin conversion from prothrombin is dependent on what vitamin? -
✔️✔️Vitamin K
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