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PHAR 100- Module 3 Exam Questions And 100% Correct Answers
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PHAR 100- Module 3 Exam Questions And 100%Correct Answers
Sedative hypnotic agents - ANSWER are CNS depressants
anti-anxiety: used to treat anxiety disorders and OCD
sedation: relives anxiety, decreases excitement, calms people
hypnosis: produces drowsiness and sleep
general anesthesia: induces a state of unconciousness
Controlling CNS excitation - ANSWER decreasing the firing of the major excitatory
neurotransmitter glutamate, will calm the brain
drug classes - ANSWER any class of drug that has the same MOA, and similar
pharmacological properties
GABA signaling - ANSWER - GABA is major inhibitory neurotransmitter in CNS
- it causes inhibition by binding with and opening chloride channels, causing hyper
polarization of the post synaptic membrane of a neuron(making it harder for neurons to
signal other neurons)
Most sedative hypnotics - ANSWER control the chloride ion channel (GABA receptor) in
the brain and spinal chord *each bond to a different site on the chloride channel8
- the result is an increase of inhibition and dampening a neuronal response
- there enhance the inhibitority effect of GABA
Drugs that bind to the chloride channels: Benzodiazepines - ANSWER
, Benzodiazepines- MOA - ANSWER activation of benzodiazepine receptor increases the
frequency of opening the chloride channel
Benzodiazepines- routes of administration - ANSWER -usually capsule or tablet
Benzodiazepines- lethality - ANSWER commonly involved with overdose (deaths from
OD are rare)
- death has occurred after large doses
Benzodiazepines- pharmacology - ANSWER - high therapeutic index
- anti-anxiety effects
- decrease aggression
- produce minimal suppression of REM sleep
- relax muscles
- anti-convlusant action
- antidote exists in case of OD
Benzodiazepines- short term use effects - ANSWER CNS:
-relaxation, anxiety relief
- drowsy, thinking/memory impared
Lungs:
- respiratory depression after intravenous administration
Motor Coordination:
- immure motor control
*responses increase as dose increases*
Benzodiazepines- long term use effects - ANSWER - some people will show signs of
sedative-hypnotic intoxication impaired thinking/memory, disorientation, slurred speech
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