Class notes
Bio 210 Chapter 10 Notes
- Course
- BIO 210
- Institution
- Greenville Technical College
This is a comprehensive and detailed note on Chapter 10- Antimicrobial Treatment *Essential Study Material!!
[Show more]
Content preview
Chapter 10: Antimicrobial TreatmentPrinciples of Antimicrobial Therapy
• The introduction of modern drugs to control infections was a medical
revolution in the 1940s.
• Antimicrobial drugs have reduced the incidence of certain infections, but
they have not eradicated infectious disease and probably never will.
• Today, doctors are worried that we are dangerously close to a post-antibiotic
era where the drugs we have are no longer effective.
• Antibiotics are common metabolic products of bacteria and fungi
– Produced to inhibit growth of competing microbes in the same habitat.
Starting Treatment
• Before actual antimicrobial therapy can begin, three factors must be known:
– What Organism?
o The nature of the microorganism causing the infection
The degree of the microorganism’s susceptibility to various drugs
The overall medical condition of the patient
Pre-existing Conditions that must be factored into treatment
plan:
• Allergies to certain drug classes
• Underlying kidney or liver disease
• Infant, elderly, or pregnant.
• Age affects absorption
• Doses for infants very critical
• Infection site (joints,brain
• Drug Interactions (what drugs patient is taking)
• Route of administration: usually liquid, by mouth. (if
person can-not swallow, IV risks infection of needle cite)
• Cost of drug
, Mechanisms of Drug Action
• Drugs must exhibit some degree of selective toxicity.
• Toxicity: important concern
– Desire drug with high selectivity and low toxicity.
– Therapeutic Index: a ratio to determine with antimicrobials what is
going to be the best job.
TI of 1.1 riskier than TI of 10
Toxic dose to human/therapeutic dose that kills organism
Toxic dose: 11 mg human / toxic dose 10 mg organism = 1.1
risky
Toxic dose: 10 mg human / toxic dose 1 mg organism= 10
Drug Failures
– Inability to diffuse into body compartment
– Resistant microbes not noted in sample tested but present in vivo
– Mixed Infection
– Patient (Drug) Compliance: finishing the course of antibiotic
• Characteristics of Ideal Antimicrobial Drug
table 10.1 pg.276
• Antimicrobial drug categories pg. 283
– Inhibition of cell wall synthesis
– Inhibition of nucleic acid structure and function
– Inhibition of protein synthesis
– Interference with cell membrane structure and function
– Inhibition of folic acid synthesis
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller anyiamgeorge19. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $12.39. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
57413 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now