D132 Final Exam Key Terms Pt.1 UPDATED ACTUAL Questions and CORRECT Answers
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Course
D132
Institution
D132
D132 Final Exam Key Terms Pt.1
UPDATED ACTUAL Questions and
CORRECT Answers
3C - CORRECT ANSWER- Chromatin Conformation Capture, which is a method for
confirming that two regions of the genome are interacting with each other in 3D inside of the
nucleus
Actionable target - CORRECT ANSWER- ...
D132 Final Exam Key Terms Pt.1
UPDATED ACTUAL Questions and
CORRECT Answers
3C - CORRECT ANSWER✔✔- Chromatin Conformation Capture, which is a method for
confirming that two regions of the genome are interacting with each other in 3D inside of the
nucleus
Actionable target - CORRECT ANSWER✔✔- A gene that is mis-expressed in a disease for
which there exists an approved drug that could be used for treatment.
Adjacency matrix: - CORRECT ANSWER✔✔- A matrix representation of a graph where
vertices are represented as row labels as well as column labels, and edges between two
vertices are represented as a non-zero number in the corresponding (row,column) entry
Allele - CORRECT ANSWER✔✔- one of the distinct versions of a gene with multiple
distinct genetic variants present in a population
Allele-specific expression - CORRECT ANSWER✔✔- Distinct expression of the two alleles
of the same gene from the two parental chromosomes.
Alternative splicing - CORRECT ANSWER✔✔- Two or more distinct combination of exons
detected in transcripts from the same gene.
ATAC-seq - CORRECT ANSWER✔✔- Assay for Transposase Accessible Chromatin
sequencing, which is a functional genomics assay used to identify regions of open chromatin
in bulk as well as in single-cells
Basic research - CORRECT ANSWER✔✔- Research done in order to understand
mechanisms of health and disease without the explicit development of a treatment for clinical
use. Basic research is distinct from translational research that would follow from the
published basic results.
, Benign - CORRECT ANSWER✔✔- A small cancerous growth that remains localized at its
tissue of origin.
Biological process (GO) - CORRECT ANSWER✔✔- Gene ontology terms that describe the
one or more biological processes or pathways that an annotated gene product can participate
in. Not to be confused with GO Molecular Function.
Biomarker - CORRECT ANSWER✔✔- A characteristic that is objectively measured and
evaluated as an indicator of normal biological processes, or pharmacologic responses to a
therapeutic intervention.
Diagnostic odyssey - CORRECT ANSWER✔✔- Multiple rounds of patient visits with
multiple specialists in order to diagnose a rare medical condition.
Carcinoma - CORRECT ANSWER✔✔- A mass of epithelial cells undergoing abnormal,
excessive growth during cancer.
cCRE - CORRECT ANSWER✔✔- a candidate cis-regulatory element (CRE) based on
functional genomic data alone.
Cellular component (GO) - CORRECT ANSWER✔✔- Gene Ontology terms that assign the
one or multiple locations where the annotated gene product functions.
Cell-free DNA (cfDNA) - CORRECT ANSWER✔✔- extra-cellular pieces of DNA that can
be recovered from blood plasma. Used for pre-natal diagnostics, liquid biopsies, and MCED
Cerebrospinal fluid (CSF) - CORRECT ANSWER✔✔- a clear, colorless fluid similar to
plasma that bathes the central nervous system and is involved in clearing waste.
ChIA-PET - CORRECT ANSWER✔✔- Chromatin Interaction Analysis using Paired-End
Tags, where long-range interactions are detected by pull-down of bound specific proteins
using an antibody
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