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AHN 577 Infectious Disease Part 2 Study Guide

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AHN 577 Infectious Disease Part 2 Study Guide Latent TB prevention - Ans:-Isoniazid x 9 months Latent TB with positive TB skin test or IGRA - Ans:-Rifampin daily x 4 months Rifampin + Pyrazinamide combo use in latent TB - Ans:-Contraindicated d/t risk for severe liver injury or death Active TB...

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  • October 23, 2024
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AHN 577 Infectious Disease Part 2 Study Guide


Latent TB prevention - Ans:✔✔-Isoniazid x 9 months


Latent TB with positive TB skin test or IGRA - Ans:✔✔-Rifampin daily x 4 months


Rifampin + Pyrazinamide combo use in latent TB - Ans:✔✔-Contraindicated d/t risk for severe liver injury

or death


Active TB treatment during intensive phase - Ans:✔✔-RIPE (Rifampin, Isoniazid, Pyrazinimide,

Ethambutol) x 8 weeks


Active TB treatment during continuation phase - Ans:✔✔-Isoniazid and Rifampin x 18 weeks


TB patient infectious if.. - Ans:✔✔-- Coughing


- Cavity in lung


- Sputum smears positive for AFB


- TB disease of lungs, airway, or larynx present


- Positive culture




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TB patient no longer infectious if.. - Ans:✔✔-- Symptoms improved AND


- 3 consecutive negative sputum smears AND


- Adhering to adequate treatment x 2 weeks


How do you test for HIV infection? - Ans:✔✔--- ELISA - initial screening; 99.9% sensitive


-- Western blot - > 99.99% sensitive and specific


Routine labs for treatment of HIV/AIDS - Ans:✔✔--- CD4 count - best indicator of immune fx; guides

therapy


-- HIV RNA - amt of actively replicating viruses; best indicator for diagnosing acute HIV infections; tells

about disease progression


-- CBC - detect pancytopenia


-- CMP - assess renal/hepatic function


-- Pregnancy test - prior to ARTs


-- UA to detect early nephropathy


-- Hgb A1c to assess for glucose intolerance


Typical initial regimen for HIV - Ans:✔✔-1 integrase inhibitor (or PI) + 2 NRTIs


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NRTI examples - Ans:✔✔-Tenofovir, Emtricitabine, Abacavir, Lamivudine


Common s/e of NRTIs - Ans:✔✔-- Hepatitis


- Neutropenia


- AKI


- Anemia


- Rash


- Peripheral neuropathy


- GI upset


NNRTI examples - Ans:✔✔-Efavirenz, Nevirapine


Common s/e of NNRTIs - Ans:✔✔-- Rash


- Peripheral neuropathy


- Depression


Protease inhibitor examples - Ans:✔✔-Darunavir, Cobistat


Common s/e of PIs - Ans:✔✔-- Hyperbilirubinemia



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