BIO 353 - Chen Exam 2 Study Guide with Complete Solutions
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Course
BIO 353
Institution
BIO 353
BIO 353 - Chen Exam 2 Study Guide with
Complete Solutions
endomembrane system - Ans:-A network of membranes inside and around a eukaryotic cell, related
either through direct physical contact or by the transfer of membranous vesicles.
Nuclear envelope, ER, GA, Lysosome, Vesicles, Endosomes, PM ...
How does nucleus get soluble proteins for DNA? - Ans:✔✔-Proteins are transported post-translationally
from cytosol (meaning in full functional form) through nuclear pores
What do proteins destined for nucleus have? And what are the two functions of this thing? - Ans:✔✔-A
sorting signal called a nuclear localization signal (NLS) which serves as both a mailing address to the
nucleus and a ticket in
What are NLSs recognized by? - Ans:✔✔-Nuclear import receptors (NIRs) aka IMPORTIN
Importin - Ans:✔✔-Nuclear import receptor (NIR)
How is protein import into nucleus accomplished? - Ans:✔✔--NLS on cargo protein recognized by NIR
which attach to cause conformational change in complex which results in high affinity to nuclear pore
tentacles in cytosol which pulls complex into the pore
-NIR grabs onto FG repeats and bounce from FG to FG, plowing way into nucleus
-Attract to basket to enter nucleus, NIR and cargo protein dissociate and cargo protein is delivered
Ran - Ans:✔✔-GTPase (has GTP on it) that can cause conformational changes essential for translocation
of protein through the NPC
Ran-GAP - Ans:✔✔-Ran-GAP (GTPase Activating Protein) helps convert Ran GTP to Ran GDP via
hydrolysis
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